Sangsopha Watchara, Kanokmedhakul Kwanjai, Lekphrom Ratsami, Kanokmedhakul Somdej
a Natural Products Research Unit, Faculty of Science, Department of Chemistry, and Center for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.
Nat Prod Res. 2018 May;32(10):1176-1179. doi: 10.1080/14786419.2017.1320787. Epub 2017 Apr 25.
Sixteen compounds were isolated from a Thai medicinal plant, Colubrina asiatica. The isolated compounds were elucidated on the basis of spectroscopic methods (IR, 1D and 2D NMR) as six triterpene acids (1-6), five steroids (7-11), one benzoic acid derivative (12), two peptides (13 and 14), one sesquiterpenoid (15) and one jujubogenin (16). Compounds 3 and 10 showed antimalarial activity against Plasmodium falciparum. Compound 5 showed antimycobacterial activity. Moreover, compounds 3, 5, 6, 10 and 14 exhibited weak cytotoxicity against cancer cell lines. Compounds 1-15 have been isolated for the first time from this plant.
从泰国药用植物亚洲蛇藤中分离出了16种化合物。通过光谱方法（红外光谱、一维和二维核磁共振）鉴定出所分离的化合物为6种三萜酸（1-6）、5种甾体（7-11）、1种苯甲酸衍生物（12）、2种肽（13和14）、1种倍半萜（15）和1种酸枣仁皂苷元（16）。化合物3和10对恶性疟原虫显示出抗疟活性。化合物5显示出抗分枝杆菌活性。此外，化合物3、5、6、10和14对癌细胞系表现出较弱的细胞毒性。化合物1-15首次从该植物中分离得到。
