从. 的根部分离得到两个新的生物活性三萜。
Two new bioactive triterpenoids from the roots of .
机构信息
Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
出版信息
Nat Prod Res. 2020 Feb;34(4):482-488. doi: 10.1080/14786419.2018.1489385. Epub 2018 Nov 16.
Two new ceanothane triterpenes, 3,7-,-dibenzoyl ceanothic acid methylester () and 3--acetyl-7--benzoyl ceanothic acid methylester (), along with nine known compounds (-), were isolated from the roots of . The isolated compounds were identified by spectroscopic evidence. Compounds and showed antimalarial activity against with IC values of 4.67 and 3.07 µg/mL, respectively. Compound also showed antimycobacterial activity against (MIC 6.25 µg/mL). In addition, compounds , , and showed cytotoxicity against three cancer cell lines (KB, NCI-H187 and MCF-7) with IC values ranging from 8.32 to 46.72 µg/mL.
从滇丁香的根部分离得到两个新的半日花烷型三萜，3,7-,-二苯甲酰滇丁香酸甲酯（）和 3--乙酰基-7--苯甲酰滇丁香酸甲酯（），以及 9 个已知化合物（-）。通过光谱证据鉴定分离得到的化合物。化合物和对疟原虫表现出抗疟活性，IC 值分别为 4.67 和 3.07μg/mL。化合物还对结核分枝杆菌表现出抗分枝杆菌活性（MIC 6.25μg/mL）。此外，化合物、、和对三种癌细胞系（KB、NCI-H187 和 MCF-7）具有细胞毒性，IC 值范围为 8.32 至 46.72μg/mL。
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