Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Nat Prod Res. 2020 Feb;34(4):482-488. doi: 10.1080/14786419.2018.1489385. Epub 2018 Nov 16.
Two new ceanothane triterpenes, 3,7-,-dibenzoyl ceanothic acid methylester () and 3--acetyl-7--benzoyl ceanothic acid methylester (), along with nine known compounds (-), were isolated from the roots of . The isolated compounds were identified by spectroscopic evidence. Compounds and showed antimalarial activity against with IC values of 4.67 and 3.07 µg/mL, respectively. Compound also showed antimycobacterial activity against (MIC 6.25 µg/mL). In addition, compounds , , and showed cytotoxicity against three cancer cell lines (KB, NCI-H187 and MCF-7) with IC values ranging from 8.32 to 46.72 µg/mL.
从滇丁香的根部分离得到两个新的半日花烷型三萜，3,7-,-二苯甲酰滇丁香酸甲酯（）和 3--乙酰基-7--苯甲酰滇丁香酸甲酯（），以及 9 个已知化合物（-）。通过光谱证据鉴定分离得到的化合物。化合物和对疟原虫表现出抗疟活性，IC 值分别为 4.67 和 3.07μg/mL。化合物还对结核分枝杆菌表现出抗分枝杆菌活性（MIC 6.25μg/mL）。此外，化合物、、和对三种癌细胞系（KB、NCI-H187 和 MCF-7）具有细胞毒性，IC 值范围为 8.32 至 46.72μg/mL。
