体能肥胖指数与阿尔茨海默病特异性死亡率

Fitness Fatness Index and Alzheimer-specific mortality.

作者信息

Frith Emily, Loprinzi Paul D

机构信息

Physical Activity Epidemiology Laboratory, Department of Health, Exercise Science and Recreation Management, University of Mississippi, MS 38677, United States; Exercise Psychology Laboratory, Department of Health, Exercise Science and Recreation Management, University of Mississippi, MS 38677, United States; Jackson Heart Study Vanguard Center of Oxford, Department of Health, Exercise Science and Recreation Management, University of Mississippi, MS 38677, United States.

出版信息

Eur J Intern Med. 2017 Jul;42:51-53. doi: 10.1016/j.ejim.2017.04.015. Epub 2017 Apr 22.

DOI:10.1016/j.ejim.2017.04.015

PMID:28442284

Abstract

OBJECTIVE

We evaluated the specific association between a Fitness Fat Index (FFI) and Alzheimer's-specific mortality among a national sample of the broader U.S. adult population.

METHODS

FFI was calculated as cardiorespiratory fitness (CRF) divided by waist-to-height ratio (WHR). Data from the 1999-2006 National Health and Nutrition Examination Survey (NHANES) were used to identify 16,146 participants, ages 20-85. Data from participants in these cycles were linked to death certificate data from the National Death Index. Person-months of follow-up were calculated from the date of the interview until date of death or censoring on December 31, 2011, whichever came first.

RESULTS

In a Cox proportional hazard model, for every 1 FFI unit increase, participants had a 14% reduced hazard of Alzheimer-specific death (HR=0.86; 95% CI: 0.83-0.90; P<0.001). When including diabetes and hypertension (via physician-diagnosis) as covariates, results were unchanged (HR=0.87; 95% CI: 0.82-0.91; P<0.001). Results were also unchanged when restricting the sample to those 50+years (HR=0.92; 95% CI: 0.88-0.97; P=0.005) or stratifying by men (HR=0.85; 95% CI: 0.81-0.91; P<0.001) or women (HR=0.86; 95% CI: 0.79-0.94; P=0.002).

CONCLUSION

In this national sample of individuals at risk for Alzheimer's disease, increased FFI was associated with reduced risk of Alzheimer's-specific death. Thus, a more favorable fitness-to-fatness ratio is associated with reduced risk of Alzheimer's-specific mortality, underscoring the importance of fitness promoting and fatness reducing strategies.

摘要

目的

我们在美国成年人群体的全国样本中评估了健康脂肪指数（FFI）与阿尔茨海默病特异性死亡率之间的具体关联。

方法

FFI的计算方法是心肺适能（CRF）除以腰高比（WHR）。利用1999 - 2006年国家健康与营养检查调查（NHANES）的数据确定了16146名年龄在20 - 85岁之间的参与者。这些周期参与者的数据与国家死亡指数的死亡证明数据相关联。随访的人月数从访谈日期计算至死亡日期或2011年12月31日的截尾日期，以先到者为准。

结果

在Cox比例风险模型中，FFI每增加1个单位，参与者阿尔茨海默病特异性死亡风险降低14%（风险比[HR]=0.86；95%置信区间[CI]：0.83 - 0.90；P<0.001）。当将糖尿病和高血压（通过医生诊断）作为协变量纳入时，结果不变（HR=0.87；95% CI：0.82 - 0.91；P<0.001）。当将样本限制为50岁及以上人群时（HR=0.92；95% CI：0.88 - 0.97；P=0.005），或者按男性（HR=0.85；95% CI：0.81 - 0.91；P<0.001）或女性（HR=0.86；95% CI：0.79 - 0.94；P=0.002）分层时，结果也不变。