Frith Emily, Loprinzi Paul D
Physical Activity Epidemiology Laboratory, Exercise Psychology Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, University, Mississippi.
Clin Cardiol. 2017 Jul;40(7):469-473. doi: 10.1002/clc.22679. Epub 2017 Mar 10.
We evaluated the specific association between a fitness-fatness index (FFI) and all-cause mortality among a national sample of US adults with coronary artery disease, congestive heart failure, or myocardial infarction. This FFI has recently emerged in the literature as a novel index of health.
We hypothesize that FFI will be inversely associated with mortality risk.
The FFI was calculated as cardiorespiratory fitness divided by waist-to-height ratio. Data from the 1999-2006 National Health and Nutrition Examination Survey were used to identify 1206 participants, ages 20 to 85. Person-months of follow-up were calculated from the date of interview until date of death or censoring on December 31, 2011, whichever came first.
In a Cox proportional hazards model, for every 1-FFI-unit increase, participants had a 6% reduced all-cause mortality rate (hazard ratio [HR]: 0.94, 95% confidence interval [CI]: 0.91-0.97, P = 0.001; N = 1206). Results were similar among those diagnosed with coronary artery disease (HR: 0.94, 95% CI: 0.90-0.98, P = 0.007), congestive heart failure (HR: 0.95, 95% CI: 0.91-0.99, P = 0.02), or myocardial infarction (HR: 0.96, 95% CI: 0.92-0.99, P = 0.04). When examined in isolation, only fitness (and not fatness) was linked with survival benefits.
In this national sample, increased FFI was associated with reduced risk of all-cause mortality; this association was driven by the beneficial effects of fitness. This underscores the importance of tailored cardiac rehabilitation programs designed to promote fitness, in particular, among cardiac populations.
我们评估了健康-肥胖指数（FFI）与美国患有冠状动脉疾病、充血性心力衰竭或心肌梗死的成年人群全因死亡率之间的特定关联。该FFI最近在文献中作为一种新的健康指标出现。
我们假设FFI与死亡风险呈负相关。
FFI的计算方法为心肺适能除以腰高比。利用1999 - 2006年国家健康与营养检查调查的数据，确定了1206名年龄在20至85岁之间的参与者。随访的人月数从访谈日期计算至死亡日期或2011年12月31日的截尾日期，以先到者为准。
在Cox比例风险模型中，FFI每增加1个单位，参与者的全因死亡率降低6%（风险比[HR]：0.94，95%置信区间[CI]：0.91 - 0.97，P = 0.001；N = 1206）。在被诊断患有冠状动脉疾病（HR：0.94，95% CI：0.90 - 0.98，P = 0.007）、充血性心力衰竭（HR：0.95，95% CI：0.91 - 0.99，P = 0.02）或心肌梗死（HR：0.96，95% CI：0.92 - 0.99，P = 0.04）的人群中，结果相似。单独分析时，只有健康状况（而非肥胖程度）与生存益处相关。
在这个全国性样本中，FFI升高与全因死亡率风险降低相关；这种关联是由健康状况的有益影响驱动的。这凸显了专门设计的旨在促进健康的心脏康复项目的重要性，特别是在心脏疾病人群中。
