Davey Sue, Ord John, Navarrete Cristina, Brown Colin
Histocompatibility & Immunogenetics Department, NHS Blood and Transplant, Colindale, London, UK.
Histocompatibility & Immunogenetics Department, NHS Blood and Transplant, Colindale, London, UK; Department of Haematololgy, University of Cambridge, UK.
Hum Immunol. 2017 May-Jun;78(5-6):397-398. doi: 10.1016/j.humimm.2017.04.001. Epub 2017 Apr 22.
Whole gene next generation sequencing was used to determine the HLA class I haplotype and allele frequencies in a cohort of 519 English blood donors. This is the first report of HLA frequencies at third field resolution in a UK population with a total of 33, 52 and 30 alleles identified for HLA-A, -B and -C, respectively. Of the 1411 haplotypes determined, 281 had a frequency of greater than 0.05%. Data are available from the Allele Frequencies Net Database under the population name 'England Blood Donors of Mixed Ethnicity', identifier 3392.
采用全基因下一代测序技术来确定519名英国献血者队列中的HLA I类单倍型和等位基因频率。这是英国人群中HLA频率在第三字段分辨率下的首次报告，分别鉴定出HLA - A、- B和- C的33、52和30个等位基因。在确定的1411个单倍型中，281个单倍型的频率大于0.05%。可从等位基因频率网络数据库中获取数据，种群名称为“英格兰混合种族献血者”，标识符为3392。
