Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria.
Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria.
J Infect Public Health. 2018 Jan-Feb;11(1):48-53. doi: 10.1016/j.jiph.2017.03.002. Epub 2017 Apr 23.
Prevalence of malaria and soil-transmitted helminth infections, and the burden of disease are enormous in sub-Saharan Africa. Co-infections aggravate the clinical outcome, but are common due to an overlap of endemic areas. A cross-sectional survey was conducted to assess prevalence, intensity of infection and association between malaria and soil-transmitted helminth infections in a typical periurban community in Kwara State. Fresh blood and faecal samples were examined using thick blood film and Kato-Katz smear techniques. A total of 383/471 study participants (81.3%) were infected with at least one parasite species, with the following prevalences and mean infection intensities: Plasmodium falciparum 63.7% (2313.6 parasites/μl); Ascaris lumbricoides 63.1% (3152.1 epg); Trichuris trichiura 53.3% (1043.5 epg); and hookworms 30.1% (981.7 epg). Sixty-three percent of the study population were co-infected with two or more parasite species. The prevalence of ascariasis was significantly higher in individuals infected with P. falciparum (adjusted OR: 5.87; 95% CI: 3.30-10.42). Heavy A. lumbricoides and T. trichiura infections were associated with high P. falciparum parasitaemia. Co-endemicity of malaria and soil transmitted helminth infections is an important public health problem in the study area. Multi-target integrated approaches focusing on disease intervention are essential to mitigate morbidity caused by multiple infections.
在撒哈拉以南非洲,疟疾和土壤传播性蠕虫感染的流行率以及疾病负担巨大。合并感染会加重临床结果,但由于流行地区重叠,合并感染很常见。进行了一项横断面调查,以评估在 Kwara 州一个典型城郊社区中疟疾和土壤传播性蠕虫感染的流行率、感染强度和两者之间的关联。使用厚血膜和加藤氏厚涂片技术检查新鲜血液和粪便样本。共有 383/471 名研究参与者(81.3%)感染了至少一种寄生虫,其流行率和平均感染强度如下:恶性疟原虫 63.7%(2313.6 条/μl);蛔虫 63.1%(3152.1 epg);鞭虫 53.3%(1043.5 epg);和钩虫 30.1%(981.7 epg)。63%的研究人群感染了两种或更多种寄生虫。感染恶性疟原虫的个体中,蛔虫病的患病率明显更高(调整后的 OR:5.87;95%CI:3.30-10.42)。重度蛔虫和鞭虫感染与恶性疟原虫高寄生虫血症有关。疟疾和土壤传播性蠕虫感染的共同流行是该研究地区一个重要的公共卫生问题。以疾病干预为重点的多目标综合方法对于减轻多种感染引起的发病率至关重要。