Østhus Ida Beate Øyen, Lydersen Stian, Dalen Håvard, Nauman Javaid, Wisløff Ulrik
K. G. Jebsen Center of Exercise in Medicine at the Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway; St. Olav's University Hospital, Trondheim, Norway.
Regional Centre for Child and Youth Mental Health and Child Welfare, Norwegian University of Science and Technology, Trondheim, Norway.
Prog Cardiovasc Dis. 2017 May-Jun;59(6):649-655. doi: 10.1016/j.pcad.2017.04.001. Epub 2017 Apr 23.
As possible markers of biological age, telomere length (TL) has been associated with age-related diseases such as myocardial infarction (MI) with conflicting findings. We sought to assess the relationship between TL and risk of future MI in 915 healthy participants (51.7% women) 65 years or older from a population-based prospective cohort (the HUNT 2 study, Norway). Mean TL was measured by quantitative PCR expressed as relative T (telomere repeat copy number) to S (single copy gene number) ratio, and log-transformed. During a mean follow up of 13.0 (SD, 3.2) years and 11,923 person-years, 82 participants were diagnosed with MI. We used Cox proportional hazard regressions to estimate hazard ratios (HR) and 95% confidence interval (CI). Relative TL was associated with age in women (P=0.01), but not in men (P=0.43). Using relative TL as a continuous variable, we observed a higher risk of MI in participants with longer telomeres with HRs of 2.46 (95% CI; 1.13 to 4.54) in men, and 2.93 (95% CI; 1.41 to 6.10) in women. Each 1-SD change in relative TL was associated with an HR of 1.54 (95% CI; 1.15 to 2.06) and 1.67 (95% CI; 1.18 to 2.37) in men and women, respectively. Compared with the bottom tertile of relative TL, HR of incident MI in top tertile was 2.71 (95% CI; 1.25 to 5.89) in men, and 3.65 (95% CI; 1.35 to 9.90) in women. Longer telomeres in healthy participants 65 years or older are associated with a high risk of incident MI. Future large scale prospective studies are needed to confirm these findings and explore the potential association between TL and MI.
作为生物年龄的潜在标志物，端粒长度（TL）已被发现与诸如心肌梗死（MI）等与年龄相关的疾病存在关联，但研究结果相互矛盾。我们试图评估在来自挪威基于人群的前瞻性队列（HUNT 2研究）中915名65岁及以上健康参与者（51.7%为女性）中端粒长度与未来发生心肌梗死风险之间的关系。平均端粒长度通过定量聚合酶链反应测量，以相对T（端粒重复拷贝数）与S（单拷贝基因数）的比值表示，并进行对数转换。在平均13.0（标准差，3.2）年的随访期内，共11923人年，82名参与者被诊断为心肌梗死。我们使用Cox比例风险回归来估计风险比（HR）和95%置信区间（CI）。相对端粒长度在女性中与年龄相关（P = 0.01），但在男性中无此关联（P = 0.43）。将相对端粒长度作为连续变量，我们观察到端粒较长的参与者发生心肌梗死的风险更高，男性的风险比为2.46（95%置信区间；1.13至4.54），女性为2.93（95%置信区间；1.41至6.10）。相对端粒长度每变化1个标准差，男性和女性的风险比分别为1.54（95%置信区间；1.15至2.06）和1.67（95%置信区间；1.18至2.37）。与相对端粒长度最低三分位数相比，最高三分位数的男性发生心肌梗死的风险比为2.71（95%置信区间；1.25至5.89），女性为3.65（95%置信区间；1.35至9.90）。65岁及以上健康参与者中较长的端粒与发生心肌梗死的高风险相关。未来需要大规模前瞻性研究来证实这些发现，并探索端粒长度与心肌梗死之间的潜在关联。
