Department of Emergency Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu 42601, Republic of Korea.
Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu 42601, Republic of Korea.
Medicina (Kaunas). 2024 Oct 10;60(10):1657. doi: 10.3390/medicina60101657.
: The association between neurological disability, prognosis, and telomere length (TL) in patients with stroke has been investigated in various ways. However, analysis of the type of stroke and ischemic stroke subgroups is limited. In this study, we aimed to determine the association between TL and neurological disability according to stroke type. : This prospective study included patients with stroke who visited a single-center emergency department (ED) between January 2022 and December 2023. The association between TL and neurological disabilities, using the Modified Rankin Scale (mRS) and National Institutes of Health Stroke Scale (NIHSS), was evaluated according to the patient's stroke type and subgroup of ischemic stroke. Multivariate analysis was performed to determine the association between neurological disabilities in patients with ischemic stroke and the subgroups. : A total of 271 patients with stroke were enrolled. The NIHSS score was found to be higher at the time of ED visit (adjusted odds ratio [OR], 5.23; 95% confidence interval [CI], 1.59-17.2, < 0.01) and 1 day later (adjusted OR, 7.78; 95% CI, 1.97-30.70, < 0.01) in the ischemic stroke group with a short TL. In the other determined etiology (OD) or undetermined etiology (UD) group, the NIHSS was higher in the short TL group at the ED visit (adjusted OR, 7.89; 95% CI, 1.32-47.25, = 0.02) and 1 day after (adjusted OR, 7.02; 95% CI, 1.14-43.47, = 0.04). : TL is associated with neurological disability in early ischemic stroke and is prominent in the UD and OD subgroups.
神经功能障碍、预后与端粒长度（TL）之间的关系已在多种研究中进行了探讨。然而，对不同类型卒中及其亚组的分析有限。本研究旨在根据卒中类型，确定 TL 与神经功能障碍之间的相关性。
这是一项前瞻性研究，纳入 2022 年 1 月至 2023 年 12 月期间在单中心急诊就诊的卒中患者。根据患者的卒中类型和缺血性卒中亚组，使用改良 Rankin 量表（mRS）和美国国立卫生研究院卒中量表（NIHSS）评估 TL 与神经功能障碍之间的相关性。采用多变量分析来确定缺血性卒中患者及其亚组的神经功能障碍与 TL 之间的相关性。
共纳入 271 例卒中患者。结果发现，TL 较短的缺血性卒中患者在 ED 就诊时（校正比值比 [OR]，5.23；95%置信区间 [CI]，1.59-17.2， < 0.01）和就诊后 1 天（校正 OR，7.78；95% CI，1.97-30.70， < 0.01）的 NIHSS 评分更高。在其他确定病因（OD）或未确定病因（UD）组中，TL 较短的患者在 ED 就诊时（校正 OR，7.89；95% CI，1.32-47.25， = 0.02）和就诊后 1 天（校正 OR，7.02；95% CI，1.14-43.47， = 0.04）的 NIHSS 评分更高。
TL 与早期缺血性卒中的神经功能障碍相关，在 UD 和 OD 亚组中更为显著。
