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一只受横纹肌溶解症和肌红蛋白尿性肾病(捕获性肌病)影响的条纹原海豚(Stenella coeruleoalba)的临床病理特征

Clinico-pathological findings in a striped dolphin (Stenella coeruleoalba) affected by rhabdomyolysis and myoglobinuric nephrosis (capture myopathy).

作者信息

Bonsembiante Federico, Centelleghe Cinzia, Rossi Gabriele, Giglio Stefania, Madeo Elena, Gelain Maria Elena, Mazzariol Sandro

机构信息

Department of Comparative Biomedicine and Food Science, University of Padua, 35020, Legnaro, Padua, Italy.

College of Veterinary Medicine, School of Veterinary and Life Science, Murdoch University, 6150, Murdoch, Perth, Western Australia.

出版信息

J Vet Med Sci. 2017 Jun 10;79(6):1013-1018. doi: 10.1292/jvms.17-0023. Epub 2017 Apr 21.

Abstract

A striped dolphin (Stenella coeruleoalba) calf stranded alive because of a Salter-Harris fracture type 1 of a caudal vertebra and remained in a provisional rehabilitation facility for 3 days where the fracture stabilization was attempted, but he died the day after bandaging. Serum and urine samples were collected during hospitalization (days 1, 2 and 3 serum and day 2 urine). Serum analysis showed increased urea, alanine transaminase, aspartate transaminase, and serum amyloid A values, while creatinine was below the lower limit. Urine analysis showed urinary protein-to-creatinine ratio of 5.3 with glomerular proteinuria. Postmortem analyses demonstrated a severe rhabdomyolysis and myoglobinuric nephrosis, suggestive of capture myopathy syndrome. We report, for the first time, the clinico-pathological changes during this condition in a striped dolphin.

摘要

一只条纹原海豚(Stenella coeruleoalba)幼崽因尾椎1型Salter-Harris骨折而存活搁浅,并在临时康复设施中停留了3天,期间尝试进行骨折固定,但在包扎后的第二天死亡。住院期间(第1、2、3天采集血清,第2天采集尿液)采集了血清和尿液样本。血清分析显示尿素、丙氨酸转氨酶、天冬氨酸转氨酶和血清淀粉样蛋白A值升高,而肌酐低于下限。尿液分析显示尿蛋白与肌酐比值为5.3,伴有肾小球蛋白尿。尸检分析显示严重横纹肌溶解和肌红蛋白尿性肾病,提示捕获性肌病综合征。我们首次报告了条纹原海豚在此种情况下的临床病理变化。

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