Sheele Johnathan Michael, Morris Nathan, Byars Donald, Counselman Frank
Department of Emergency Medicine, University Hospitals Cleveland Medical Center & Case Western Reserve University, Cleveland, OH 44106, USA.
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.
Indian J Sex Transm Dis AIDS. 2017 Jan-Jun;38(1):60-64. doi: 10.4103/0253-7184.203438.
Proton pump inhibitors (PPIs) have been shown in cell culture to kill (TV) at lower half maximal inhibitory concentration values than metronidazole (Flagyl), the most common medication used to treat the infection. However, there have been no previous clinical investigations to determine if PPIs are associated with reduced risk for TV.
We examined the records of female patients who received testing in the emergency department for TV, (GC), and (CT) between 2010 and 2014 at two academic medical centers to determine if PPI and histamine type 2 receptor antagonist (H2RA) drugs were associated with TV and GC/CT infections.
We found that H2RAs were associated with an increased likelihood for TV (odds ratio [OR]: 2.0, < 0.0001) and GC and/or CT infections (OR: 1.49, < 0.0001). PPIs were associated with a reduced likelihood for TV (OR: 0.75, < 0.0001) and GC and/or CT infections (OR: 0.57, < 0.0001). In patients infected with GC and/or CT, the likelihood of coinfection with TV was reduced in those taking a PPI (OR: 0.64, = 0.054) and increased in those taking an H2RA (OR: 1.62, = 0.003).
PPIs are associated with a reduced risk for TV and GC/CT infection.
在细胞培养中已表明，质子泵抑制剂（PPI）在达到半数最大抑制浓度值时杀灭沙眼衣原体（TV）的效果优于甲硝唑（灭滴灵），后者是治疗该感染最常用的药物。然而，此前尚无临床研究确定PPI是否与降低TV感染风险相关。
我们查阅了2010年至2014年间在两家学术医疗中心急诊科接受TV、淋病奈瑟菌（GC）和沙眼衣原体（CT）检测的女性患者记录，以确定PPI和2型组胺受体拮抗剂（H2RA）药物是否与TV及GC/CT感染相关。
我们发现H2RA与TV感染可能性增加相关（比值比[OR]：2.0，P<0.0001）以及与GC和/或CT感染相关（OR：1.49，P<0.0001）。PPI与TV感染可能性降低相关（OR：0.75，P<0.0001）以及与GC和/或CT感染相关（OR：0.57，P<0.0001）。在感染GC和/或CT的患者中，服用PPI的患者合并感染TV的可能性降低（OR：0.64，P = 0.054），而服用H2RA的患者合并感染TV的可能性增加（OR：1.62，P = 0.003）。
PPI与降低TV及GC/CT感染风险相关。
