Khan Ayesha, Fortenberry J Dennis, Juliar Beth E, Tu Wanzhu, Orr Donald P, Batteiger Byron E
Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Sex Transm Dis. 2005 Apr;32(4):260-4. doi: 10.1097/01.olq.0000161089.53411.cb.
Treatment of sex partners by patient-delivered partner therapy (PDPT) may prove to be an effective strategy in reducing reinfection and preventing the sequelae of sexually transmitted infections (STIs). However, limited data exists regarding STIs within sexual partnerships (dyads).
The objective of this study was to determine the prevalence of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (GC), and Trichomonas vaginalis (TV) in sexual dyads to estimate the potential yield and limitations of PDPT.
Male and female STI clinic attendees were invited to participate. Index subjects and partners were interviewed and tested for CT, GC, and TV. All partners were sought regardless of infection status of the index subject.
Of 210 dyads, the prevalence in index subjects was CT, 46%; GC, 18%; and TV, 14%. Considering the partners of 72 CT-only-infected index subjects, 57% had CT, 6% had GC, and 11% had TV. Considering the partners of 35 index subjects with GC or GC-CT coinfection, 57% had GC and/or CT; however, in 20% of partners, unsuspected TV was present. Among 74 dyads with uninfected index subjects, 26% of partners had an STI. Among the partners of 19 index subjects with TV only, 11% had CT, 5% had GC, and 37% had TV.
In our clinic population, a substantial number of partners had infections different from or in addition to those infections in the index. Many of these infected partners would not be diagnosed and treated using PDPT. Partners of index attendees without detected infection were at high risk (26%) for STI, mostly CT.
由患者主导的性伴治疗（PDPT）可能是减少再感染和预防性传播感染（STIs）后遗症的有效策略。然而，关于性伴侣关系（二元组）中性传播感染的数据有限。
本研究的目的是确定沙眼衣原体（CT）、淋病奈瑟菌（GC）和阴道毛滴虫（TV）在性伴侣关系中的患病率，以评估PDPT的潜在收益和局限性。
邀请男性和女性性传播感染门诊患者参与。对索引病例及其性伴侣进行访谈，并检测CT、GC和TV。无论索引病例的感染状况如何，均寻找其所有性伴侣。
在210对性伴侣中，索引病例中CT的患病率为46%，GC为18%，TV为14%。考虑72例仅感染CT的索引病例的性伴侣，57%患有CT，6%患有GC，11%患有TV。考虑35例患有GC或GC-CT合并感染的索引病例的性伴侣，57%患有GC和/或CT；然而，20%的性伴侣存在未被怀疑的TV感染。在74对索引病例未感染的性伴侣中，26%的性伴侣患有性传播感染。在19例仅感染TV的索引病例的性伴侣中，11%患有CT，5%患有GC，37%患有TV。
在我们的门诊患者中，相当数量的性伴侣感染与索引病例不同或除索引病例感染外还存在其他感染。许多这些感染的性伴侣无法通过PDPT被诊断和治疗。未检测到感染的索引病例的性伴侣性传播感染风险较高（26%），主要是CT感染。
