Castillo Lara Maria, Martínez Herrera Antonia, Torrejón Cardoso Rafael, Lubián López Daniel Maria
Department of Obstetrics and Gynecology, Hospital Universitario Puerto Real, Cádiz, Spain.
Breast Cancer (Dove Med Press). 2017 Apr 11;9:245-248. doi: 10.2147/BCTT.S131446. eCollection 2017.
Granular cell tumor (GCT) is a rare neoplasm of the soft tissues, and <1% of all GCTs are malignant. It usually appears in the tongue and sometimes may affect the female breast. Initially, GCT was considered to be a myogenic lesion affecting female breast (myoblastoma). Actually, it is assumed as a tumor originating from perineural or putative Schwann cells of peripheral nerves or their precursors that grows in the lobular breast tissue, due to the immunohistochemical features. Here, we review the importance of differentiating between this tumor and malignant breast carcinoma. Mammographically, by ultrasound scan and clinically, this case appears to be a malignant tumor of the breast, but with a correct and precise diagnosis including histopathologic examination and immunohistochemical studies, it was correctly identified as a GCT.
We present a case of a 52-year-old premenopausal woman. This report is of interest because of patient's familial oncologic history and personal history of gynecologic cancer. This rare tumor of the breast and the special way to approach the tumor by local anesthesia makes it interesting to communicate.
This is a case of interest because GCT located in the breast is very unusual and knowledge of GCT is required for the differential diagnosis with breast cancer.
颗粒细胞瘤（GCT）是一种罕见的软组织肿瘤，所有GCT中恶性的比例不到1%。它通常出现在舌部，有时也可能影响女性乳房。最初，GCT被认为是一种影响女性乳房的肌源性病变（成肌细胞瘤）。实际上，由于免疫组化特征，它被认为是一种起源于周围神经的神经周或假定的施万细胞或其前体细胞的肿瘤，生长在乳腺小叶组织中。在此，我们回顾了鉴别这种肿瘤与乳腺恶性癌的重要性。在乳腺钼靶、超声扫描及临床检查中，该病例看似乳腺恶性肿瘤，但通过包括组织病理学检查和免疫组化研究在内的正确而精确的诊断，它被正确鉴定为颗粒细胞瘤。
我们报告一例52岁绝经前女性病例。由于患者的家族肿瘤病史和妇科癌症个人史，本报告具有一定意义。这种罕见的乳腺肿瘤以及通过局部麻醉处理肿瘤的特殊方式使其具有交流价值。
这是一个值得关注的病例，因为位于乳腺的颗粒细胞瘤非常罕见，且在与乳腺癌进行鉴别诊断时需要了解颗粒细胞瘤相关知识。
