舒更葡糖钠用于逆转神经肌肉阻滞并为运动诱发电位监测提供最佳条件。
Sugammadex to reverse neuromuscular blockade and provide optimal conditions for motor-evoked potential monitoring.
作者信息
Trifa Mehdi, Krishna Senthil, D'Mello Ajay, Hakim Mumin, Tobias Joseph Drew
机构信息
Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.
出版信息
Saudi J Anaesth. 2017 Apr-Jun;11(2):219-221. doi: 10.4103/1658-354X.203024.
Abstract
Sugammadex is a novel pharmacologic agent, which reverses neuromuscular blockade (NMB) via a mechanism that differs completely from acetylcholinesterase inhibitors. By encapsulating rocuronium, sugammadex can provide recovery of neuromuscular function even when there is a profound degree of NMB. We report anecdotal experience with the use of sugammadex to reverse NMB to facilitate intraoperative neurophysiological monitoring (motor evoked potentials) in an adolescent with scoliosis during posterior spinal fusion. Its potential application in this unique clinical scenario is discussed, and potential dosing schemes are reviewed.
摘要
舒更葡糖钠是一种新型药物，它通过一种与乙酰胆碱酯酶抑制剂完全不同的机制来逆转神经肌肉阻滞（NMB）。通过包裹罗库溴铵，即使存在深度神经肌肉阻滞，舒更葡糖钠也能使神经肌肉功能恢复。我们报告了在一名患有脊柱侧弯的青少年进行后路脊柱融合手术期间，使用舒更葡糖钠逆转神经肌肉阻滞以促进术中神经生理监测（运动诱发电位）的轶事性经验。讨论了其在这种独特临床情况中的潜在应用，并回顾了潜在的给药方案。
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