一例伴有多个肺囊肿的免疫球蛋白G4相关性呼吸道疾病：病例报告
A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report.
作者信息
Mikumo Hironori, Hamada Naoki, Harada Eiji, Yanagihara Toyoshi, Ogata Saiko, Yabuuchi Hidetake, Ijichi Kayo, Takayama Koichi, Nakanishi Yoichi
机构信息
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
出版信息
Respir Med Case Rep. 2017 Apr 8;21:89-92. doi: 10.1016/j.rmcr.2017.03.023. eCollection 2017.
A 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD). Histologic findings of the cervical lymph node and right lung S biopsies revealed numerous IgG4-positive plasma cells. Although CT findings of the lungs were atypical for IgG4-RD, consistent histologic findings, clinical symptoms, and laboratory data made us conclude IgG4-RD. Because histologic findings of IgG4-RD and MCD have similarities, differentiating between the two diseases should consider the clinical presentation.
一名48岁男性因胸部X线片出现异常阴影入院评估。胸部计算机断层扫描（CT）显示有囊肿、结节以及颈部和腋窝淋巴结肿大。血清IgG4和白细胞介素（IL）-6水平升高提示IgG4相关性疾病（IgG4-RD）或多中心Castleman病（MCD）。颈部淋巴结和右肺S活检的组织学检查发现大量IgG4阳性浆细胞。尽管肺部CT表现不符合IgG4-RD的典型表现，但一致的组织学检查结果、临床症状和实验室数据使我们诊断为IgG4-RD。由于IgG4-RD和MCD的组织学表现有相似之处，鉴别这两种疾病应考虑临床表现。
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