[β-肾上腺素能激动剂异丙肾上腺素的特征活性与细胞膜渗透特性之间的关系]

[Relation between the characteristic activity of the beta-adrenergic agonist isoproterenol and the percolation properties of cell membrane].

作者信息

Kazarov A R, Rozenkrants A A, Sobolev A S

出版信息

Biull Eksp Biol Med. 1988 Sep;106(9):319-21.

Abstract

Variations in the intrinsic activity of 1-isoproterenol and in the percentage of high affinity beta-receptor complexes have been studied under a changes in the macrostructure of reticulocyte plasma membranes. The fluid lipid fraction have been reduced in the membranes for this by phospholipase A2/BSA treatment. It was accompanied by a progressive decrease in the fraction of beta-receptors that are able to form the high affinity complexes with 1-isoproterenol (receptor--regulatory N-protein complexes). Evaluated with the ability to activate the adenylate cyclase, the intrinsic activity of 1-isoproterenol was decreased from 1 to 0 under with conditions. This variations proved to correlate strongly with each other. Thus, changes in the membrane macrostructure may directly determine an efficiency of hormone actions.

摘要

在网织红细胞质膜宏观结构发生变化的情况下，研究了1-异丙肾上腺素的内在活性变化以及高亲和力β受体复合物的百分比。为此，通过磷脂酶A2/牛血清白蛋白处理使膜中的流动性脂质部分减少。这伴随着能够与1-异丙肾上腺素形成高亲和力复合物的β受体部分（受体 - 调节性N蛋白复合物）的逐渐减少。用激活腺苷酸环化酶的能力评估，在这些条件下1-异丙肾上腺素的内在活性从1降至0。事实证明，这些变化彼此密切相关。因此，膜宏观结构的变化可能直接决定激素作用的效率。

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