64628例患者中桥本甲状腺炎与甲状腺癌的关联
Association between Hashimoto's Thyroiditis and Thyroid Cancer in 64,628 Patients.
作者信息
Resende de Paiva Christina, Grønhøj Christian, Feldt-Rasmussen Ulla, von Buchwald Christian
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Department of Medical Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
出版信息
Front Oncol. 2017 Apr 10;7:53. doi: 10.3389/fonc.2017.00053. eCollection 2017.
BACKGROUND
The incidence of thyroid cancer (TC) is increasing although explanatory causes are lacking. A link between cancer and inflammation is well documented but unclear for autoimmune thyroid diseases and TC. We aimed to systematically review the association between Hashimoto's thyroiditis (HT) and papillary, follicular, medullary, anaplastic thyroid carcinoma, and thyroid lymphoma (TL).
METHODS
PubMed, OVID Medline, Google Scholar, and the Cochrane Library were searched from 1955 to 2016. The inclusion criteria were age >18 years, ≥20 cases of HT or TC. We collectively examined the incidence of HT in TC and of TC in HT.
RESULTS
We identified 36 studies (64,628 subjects) published between 1955 and 2016 from 13 countries. We found a relative risk (RR) of HT among papillary thyroid cancer (PTC) of 2.36 [95% confidence intervals (CIs) 1.55-3.29, < 0.001], an RR of PTC among HT of 1.40 (95% CI 1.07-1.85, = 0.016), and an RR of TL among HT of 9.74 (95% CI 3.93-24.13, < 0.001).
CONCLUSION
We report an association between HT and PTC and between HT and TL. No association was found between HT and follicular, medullary, or anaplastic thyroid cancer.
背景
甲状腺癌（TC）的发病率正在上升，尽管其病因尚不明确。癌症与炎症之间的联系已有充分记录，但自身免疫性甲状腺疾病与TC之间的关系尚不清楚。我们旨在系统评价桥本甲状腺炎（HT）与乳头状、滤泡状、髓样、未分化甲状腺癌以及甲状腺淋巴瘤（TL）之间的关联。
方法
检索1955年至2016年期间的PubMed、OVID Medline、谷歌学术和考克兰图书馆。纳入标准为年龄>18岁，HT或TC病例≥20例。我们共同检查了TC中HT的发病率以及HT中TC的发病率。
结果
我们从13个国家中识别出1955年至2016年期间发表的36项研究（64628名受试者）。我们发现乳头状甲状腺癌（PTC）中HT的相对风险（RR）为2.36[95%置信区间（CI）1.55 - 3.29，<0.001]，HT中PTC的RR为1.40（95%CI 1.07 - 1.85，=0.016），HT中TL的RR为9.74（95%CI 3.93 - 24.13，<0.001）。
结论
我们报告了HT与PTC之间以及HT与TL之间存在关联。未发现HT与滤泡状、髓样或未分化甲状腺癌之间存在关联。
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