Cabral Silvia, Bonfim Cristine, Oliveira Rosalira, Oliveira Paula, Guimarães Terezinha, Brandão Eduardo, Aguiar-Santos Ana Maria, Medeiros Zulma
Fundação Oswaldo Cruz, Centro de Pesquisa Aggeu Magalhães, Programa de Doutorado em Saúde Pública, Pernambuco, Brazil.
Fundação Joaquim Nabuco, Departamento de Pesquisa Social, Pernambuco, Brazil.
Rev Inst Med Trop Sao Paulo. 2017 Apr 20;59:e23. doi: 10.1590/S1678-9946201759023.
The aim of this study was to investigate the epidemiological characteristics, antigenic profile, perceptions, attitudes and practices of individuals who have been systematically non-compliant in mass drug administration (MDA) campaigns targeting lymphatic filariasis, in the municipality of Olinda, State of Pernambuco, Northeastern Brazil. A pretested questionnaire was used to obtain information on socioenvironmental demographics, perceptions of lymphatic filariasis and MDA, and reasons for systematic noncompliance with treatment. A rapid immunochromatographic test (ICT) was performed during the survey to screen for filariasis. It was found that the survey subjects knew about filariasis and MDA. Filariasis was identified as a disease (86.2%) and 74.4% associated it with the presence of swelling in the legs. About 80% knew about MDA, and the main source of information was healthcare workers (68.3%). For men the main reasons for systematic noncompliance with MDA were that "the individual had not received the medication" (p=0.03) and for women "the individual either feared experiencing adverse reactions". According to the ICT, the prevalence of lymphatic filariasis was 2%. The most important causes of systematic noncompliance were not receiving the drug and fear of side-effects. For successful implementation of MDA programs, good planning, educational campaigns promoting the benefits of MDA, adoption of measures to minimize the impact of adverse effects and improvement of drug distribution logistics are needed.
本研究旨在调查巴西东北部伯南布哥州奥林达市在针对淋巴丝虫病的群体药物管理（MDA）活动中系统性不依从的个体的流行病学特征、抗原谱、认知、态度和行为。使用经过预测试的问卷获取有关社会环境人口统计学、对淋巴丝虫病和MDA的认知以及系统性不依从治疗的原因的信息。在调查期间进行了快速免疫层析试验（ICT）以筛查丝虫病。结果发现，调查对象了解丝虫病和MDA。86.2%的人将丝虫病识别为一种疾病，74.4%的人将其与腿部肿胀联系起来。约80%的人了解MDA，主要信息来源是医护人员（68.3%）。对于男性，系统性不依从MDA的主要原因是“个人未收到药物”（p=0.03），对于女性则是“个人害怕出现不良反应”。根据ICT检测，淋巴丝虫病的患病率为2%。系统性不依从的最重要原因是未收到药物和害怕副作用。为了成功实施MDA项目，需要进行良好的规划、开展宣传MDA益处的教育活动、采取措施尽量减少不良反应的影响以及改善药物分发物流。
