Askari Sahar, Imani Alireza, Sadeghipour Hamidreza, Faghihi Mahdieh, Edalatyzadeh Zohreh, Choopani Samira, Karimi Nasser, Fatima Sulail
Tehran University of Medical Sciences, Tehran, Iran.
Rassoul Akram Hospital - Iran University of Medical Sciences, Tehran, Iran.
Arq Bras Cardiol. 2017 May;108(5):443-451. doi: 10.5935/abc.20170042. Epub 2017 Apr 20.
Cardiovascular diseases are the leading cause of mortality and long-term disability worldwide. Various studies have suggested a protective effect of lactation in reducing the risk of cardiovascular diseases.
This study was designed to assess the effects of pregnancy and lactation on the vulnerability of the myocardium to an ischemic insult.
Eighteen female rats were randomly divided into three groups: ischemia-reperfusion (IR), in which the hearts of virgin rats underwent IR (n = 6); lactating, in which the rats nursed their pups for 3 weeks and the maternal hearts were then submitted to IR (n = 6); and non-lactating, in which the pups were separated after birth and the maternal hearts were submitted to IR (n = 6). Outcome measures included heart rate (HR), left ventricular developed pressure (LVDP), rate pressure product (RPP), ratio of the infarct size to the area at risk (IS/AAR %), and ventricular arrhythmias - premature ventricular contraction (PVC) and ventricular tachycardia (VT).
The IS/AAR was markedly decreased in the lactating group when compared with the non-lactating group (13.2 ± 2.5 versus 39.7 ± 3.5, p < 0.001) and the IR group (13.2 ± 2.5 versus 34.0 ± 4.7, p < 0.05). The evaluation of IR-induced ventricular arrhythmias indicated that the number of compound PVCs during ischemia, and the number and duration of VTs during ischemia and in the first 5 minutes of reperfusion in the non-lactating group were significantly (p < 0.05) higher than those in the lactating and IR groups.
Lactation induced early-onset cardioprotective effects, while rats that were not allowed to nurse their pups were more susceptible to myocardial IR injury.
心血管疾病是全球范围内导致死亡和长期残疾的主要原因。各种研究表明，哺乳对降低心血管疾病风险具有保护作用。
本研究旨在评估妊娠和哺乳对心肌对缺血性损伤易感性的影响。
18只雌性大鼠随机分为三组：缺血再灌注组（IR），即未生育的大鼠心脏接受缺血再灌注（n = 6）；哺乳组，大鼠哺乳幼崽3周，然后其母心脏接受缺血再灌注（n = 6）；非哺乳组，幼崽出生后即分开，其母心脏接受缺血再灌注（n = 6）。观察指标包括心率（HR）、左心室舒张末压（LVDP）、心率血压乘积（RPP）、梗死面积与危险面积之比（IS/AAR%）以及室性心律失常——室性早搏（PVC）和室性心动过速（VT）。
与非哺乳组（13.2±2.5对39.7±3.5，p<）和IR组（13.2±2.5对34.0±4.7，p<）相比，哺乳组的IS/AAR明显降低。对缺血再灌注诱导的室性心律失常的评估表明，非哺乳组在缺血期间复合PVC的数量以及在缺血期间和再灌注前5分钟内VT的数量和持续时间均显著（p<）高于哺乳组和IR组。
哺乳可诱导早期心脏保护作用，而不允许哺乳幼崽的大鼠对心肌缺血再灌注损伤更敏感。 0.001 0.05
