生理和病理条件下骨骼肌中DNA完整性的调控
Control of DNA integrity in skeletal muscle under physiological and pathological conditions.
作者信息
Bou Saada Yara, Zakharova Vlada, Chernyak Boris, Dib Carla, Carnac Gilles, Dokudovskaya Svetlana, Vassetzky Yegor S
机构信息
UMR 8126, CNRS, Univ. Paris-Sud, Université Paris Saclay, Institut de Cancérologie Gustave-Roussy, 94805, Villejuif, France.
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 117334, Russia.
出版信息
Cell Mol Life Sci. 2017 Oct;74(19):3439-3449. doi: 10.1007/s00018-017-2530-0. Epub 2017 Apr 25.
Abstract
Skeletal muscle is a highly oxygen-consuming tissue that ensures body support and movement, as well as nutrient and temperature regulation. DNA damage induced by reactive oxygen species is present in muscles and tends to accumulate with age. Here, we present a summary of data obtained on DNA damage and its implication in muscle homeostasis, myogenic differentiation and neuromuscular disorders. Controlled and transient DNA damage appears to be essential for muscular homeostasis and differentiation while uncontrolled and chronic DNA damage negatively affects muscle health.
摘要
骨骼肌是一种高耗氧组织，可确保身体支撑和运动，以及营养和温度调节。活性氧诱导的DNA损伤存在于肌肉中，并倾向于随着年龄的增长而积累。在这里，我们总结了关于DNA损伤及其在肌肉稳态、肌源性分化和神经肌肉疾病中的影响所获得的数据。可控的短暂DNA损伤似乎对肌肉稳态和分化至关重要，而不受控的慢性DNA损伤则会对肌肉健康产生负面影响。
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