Folkhälsan Research Center, Topeliuksenkatu 20, 00250, Helsinki, Finland.
Gerontology Research Center and Department of Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland.
Osteoporos Int. 2017 Sep;28(9):2717-2722. doi: 10.1007/s00198-017-4048-6. Epub 2017 Apr 25.
We examined the associations between childhood growth and bone properties among women at early old age. Early growth in height predicted greater bone area and higher bone mineral mass. However, information on growth did not improve prediction of bone properties beyond that predicted by body size at early old age.
We examined the associations between body size at birth and childhood growth with bone area, bone mineral content (BMC), and areal bone mineral density (aBMD) in early old age.
A subgroup of women (n = 178, mean 60.4 years) from the Helsinki Birth Cohort Study, born 1934-1944, participated in dual-energy X-ray absorptiometry (DXA) measurements of the lumbar spine and hip. Height and weight at 0, 2, 7, and 11 years, obtained from health care records, were reconstructed into conditional variables representing growth velocity independent of earlier growth. Weight was adjusted for corresponding height. Linear regression models were adjusted for multiple confounders.
Birth length and growth in height before 7 years of age were positively associated with femoral neck area (p < 0.05) and growth in height at all age periods studied with spine bone area (p < 0.01). Growth in height before the age of 7 years was associated with BMC in the femoral neck (p < 0.01) and birth length and growth in height before the age of 7 years were associated with BMC in the spine (p < 0.05). After entering adult height into the models, nearly all associations disappeared. Weight gain during childhood was not associated with bone area or BMC, and aBMD was not associated with early growth.
Optimal growth in height in girls is important for obtaining larger skeleton and consequently higher bone mass. However, when predicting bone mineral mass among elderly women, information on early growth does not improve prediction beyond that predicted by current height and weight.
研究在老年早期，女性儿童期生长与骨骼特性之间的相关性。儿童时期的身高增长预示着更大的骨面积和更高的骨矿物质含量。然而，与早期成年身高相比，生长信息并不能改善对骨骼特性的预测。
对赫尔辛基出生队列研究中的一个亚组女性（n=178，平均年龄 60.4 岁）进行双能 X 射线吸收法（DXA）腰椎和髋部测量。通过医疗记录获取 0、2、7 和 11 岁时的身高和体重，并重建为条件变量，以表示与早期生长无关的生长速度。体重与相应的身高进行了调整。线性回归模型调整了多个混杂因素。
出生时的长度和 7 岁前的身高增长与股骨颈面积呈正相关（p<0.05），所有研究阶段的身高增长与脊柱骨面积呈正相关（p<0.01）。7 岁前的身高增长与股骨颈的 BMC 相关（p<0.01），出生时的长度和 7 岁前的身高增长与脊柱的 BMC 相关（p<0.05）。将成年身高纳入模型后，几乎所有的关联都消失了。儿童时期的体重增加与骨面积或 BMC 无关，aBMD 与早期生长无关。
女孩身高的最佳增长对于获得更大的骨骼并因此获得更高的骨量很重要。然而，在预测老年女性的骨矿物质含量时，早期生长信息并不能改善预测，而只能预测当前身高和体重。
