Ghamlouch Hussein, Nguyen-Khac Florence, Bernard Olivier A
Institut National De La Santé Et De La Recherche Médicale (INSERM) U1170, Villejuif, France.
Gustave Roussy, Villejuif, France.
Br J Haematol. 2017 Sep;178(6):852-870. doi: 10.1111/bjh.14719. Epub 2017 Apr 25.
Massive genomic analyses have underscored the diversity of chronic lymphocytic leukaemia (CLL) between patients. Genetic heterogeneity of tumour clones within a patient may fuel tumour evolution. Several recurrently deregulated intra-cellular pathways are candidates for targeted therapies that are very promising and are dramatically changing clinical patients' perspectives. In this review we present an overview of the genetic and epigenetic features of CLL and their clinical and biological implications.
大规模基因组分析突显了慢性淋巴细胞白血病（CLL）患者之间的多样性。患者体内肿瘤克隆的基因异质性可能推动肿瘤进展。几种反复失调的细胞内信号通路是靶向治疗的候选对象，这些治疗前景广阔，正在极大地改变临床治疗格局。在本综述中，我们概述了CLL的遗传和表观遗传特征及其临床和生物学意义。
