Haem augments and iron chelation decreases toll-like receptor 4 mediated inflammation in monocytes from sickle cell patients.
作者信息
Dagur Pradeep K, McCoy J Philip, Nichols James, Mendelsohn Laura, Seamon Catherine, Kato Gregory J, van Beers Eduard J
机构信息
Hematology Branch and Flow Cytometry Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Division of Hematology-Oncology and Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
Br J Haematol. 2018 May;181(4):552-554. doi: 10.1111/bjh.14663. Epub 2017 Apr 26.
Abstract
摘要
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Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.血红素结合蛋白疗法可逆转镰状细胞病小鼠模型中血红素诱导的巨噬细胞促炎表型转换。
Blood. 2016 Jan 28;127(4):473-86. doi: 10.1182/blood-2015-08-663245. Epub 2015 Dec 16.
3
Iron, inflammation, and early death in adults with sickle cell disease.镰状细胞病成人患者的铁、炎症与早期死亡
Circ Res. 2015 Jan 16;116(2):298-306. doi: 10.1161/CIRCRESAHA.116.304577. Epub 2014 Nov 6.
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H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice.转铁蛋白亚铁氧化酶诱导转基因镰状细胞小鼠的细胞保护途径并抑制微血管淤滞。
Front Pharmacol. 2014 Apr 17;5:79. doi: 10.3389/fphar.2014.00079. eCollection 2014.
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