Department of Diabetology, Nara Medical University, Kashihara, Nara, Japan.
Department of Endocrinology, Tenri Hospital, Tenri, Nara, Japan.
Diabetes Metab Res Rev. 2017 Oct;33(7). doi: 10.1002/dmrr.2905. Epub 2017 Jun 16.
We assessed the prospective association between baseline serum uric acid levels and consequent risk of developing diabetic retinopathy.
Data for 1839 type 2 diabetes patients without diabetic retinopathy were obtained from a Japanese diabetes registry. A Cox proportional hazards model with time-varying exposure information by sex was used and adjusted for potential confounders to assess the independent correlations between baseline serum uric acid levels and incidence rate of diabetic retinopathy.
Newly developed diabetic retinopathy was recognized in 188 patients (10.2%) during the observation period of 2 years. Compared to the first serum uric acid quartile level, the multivariate adjusted hazards ratio for diabetic retinopathy development in male patients was 1.97 (95% CI, 1.14-3.41; P = .015), 1.92 (95% CI, 1.18-3.13; P = .008), and 2.17 (95% CI, 1.40-3.37; P = .001) for the second, third, and fourth serum uric acid quartile levels, respectively. But this was not the case with female patients.
Higher serum uric acid levels were associated with increased risk of developing diabetic retinopathy in male patients with type 2 diabetes, but not in female patients. Serum uric acid may be a useful biomarker for predicting the future risk of developing diabetic retinopathy in male patients with type 2 diabetes.
我们评估了基线血清尿酸水平与随后发生糖尿病视网膜病变风险之间的前瞻性关联。
从日本糖尿病注册处获得了 1839 名无糖尿病视网膜病变的 2 型糖尿病患者的数据。使用具有性别时变暴露信息的 Cox 比例风险模型，并调整了潜在混杂因素，以评估基线血清尿酸水平与糖尿病视网膜病变发生率之间的独立相关性。
在 2 年的观察期内，188 名（10.2%）患者新确诊为糖尿病视网膜病变。与第一血清尿酸四分位水平相比，男性患者新发糖尿病视网膜病变的多变量校正风险比为 1.97（95%CI，1.14-3.41；P=0.015）、1.92（95%CI，1.18-3.13；P=0.008）和 2.17（95%CI，1.40-3.37；P=0.001），分别为第二、第三和第四血清尿酸四分位水平。但女性患者并非如此。
较高的血清尿酸水平与 2 型男性糖尿病患者发生糖尿病视网膜病变的风险增加相关，但与女性患者无关。血清尿酸可能是预测 2 型男性糖尿病患者未来发生糖尿病视网膜病变风险的有用生物标志物。
