Department of Rheumatology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
Transl Vis Sci Technol. 2022 Aug 1;11(8):9. doi: 10.1167/tvst.11.8.9.
To explore the relationship between serum uric acid (SUA) and retinochoroidal microcirculation in the Chinese population.
This prospective cross-sectional study was conducted among the residents of Guangzhou, southern China. A commercially available optical coherence tomography angiography (OCTA) device was used to obtain the superficial vessel density (SVD) and deep vessel density in the retina and the choriocapillaris flow deficit (CFD) in the macular region. Univariable and multivariable linear regression models were used to assess the association of hyperuricemia and SUA levels with OCTA parameters.
A total of 638 participants with normal SUA and 296 participants with hyperuricemia were included in the study. Parafoveal SVD was significantly reduced among the participants with hyperuricemia compared to participants with normal SUA (P < 0.001), while the parafoveal CFD was higher in hyperuricemic participants than those of normal SUA levels (P = 0.007). After adjusting for potential confounders, greater SUA levels was associated with lower SVD (β = -0.078; P < 0.001) and greater CFD (β = 0.015; P = 0.011). Gender difference analysis indicated that a 10-µmol/L increase in SUA levels among the female participants led to a 0.144 decrease in SVD (P < 0.001), but it was not statistically significant for the male participants (P = 0.653).
An elevated uric acid level and its fluctuations were independently associated with impaired retinal and choroidal microcirculation using OCTA in the study population. Women appear to be more sensitive to high SUA levels than men.
Elevating uric acid concentration may play a role in the development and progression of cardiovascular diseases through microvascular alteration, as demonstrated by OCTA parameters.
探讨中国人群血清尿酸（SUA）与视网膜脉络膜微循环的关系。
本前瞻性横断面研究在中国南方广州市居民中进行。使用商用光学相干断层扫描血管造影（OCTA）设备获取视网膜浅层血管密度（SVD）和深层血管密度以及黄斑区脉络膜毛细血管血流不足（CFD）。采用单变量和多变量线性回归模型评估高尿酸血症和 SUA 水平与 OCTA 参数的关系。
共纳入 638 例 SUA 正常和 296 例高尿酸血症患者。与 SUA 正常者相比，高尿酸血症患者的旁中心 SVD 明显降低（P < 0.001），而高尿酸血症患者的旁中心 CFD 较高（P = 0.007）。调整潜在混杂因素后，SUA 水平越高，SVD 越低（β = -0.078；P < 0.001），CFD 越高（β = 0.015；P = 0.011）。性别差异分析表明，女性参与者 SUA 水平每增加 10 µmol/L，SVD 降低 0.144（P < 0.001），但男性参与者无统计学意义（P = 0.653）。
在研究人群中，尿酸水平升高及其波动与 OCTA 检测到的视网膜和脉络膜微循环受损独立相关。女性对高 SUA 水平的敏感性似乎高于男性。
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