Jitariu Adriana-Andreea, Cîmpean Anca Maria, Ribatti Domenico, Raica Marius
Department of Microscopic Morphology/Histology, Angiogenesis Research Center, Victor Babeș University of Medicine and Pharmacy, Timișoara, Romania.
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Oncotarget. 2017 Jul 11;8(28):46652-46662. doi: 10.18632/oncotarget.16938.
One of the most controversial women malignancies, triple negative breast cancers (TNBCs) are critically overviewed here, being focused on data useful in clinical practice or to improve the therapy and patients survival. TNBCs "choose" young women and its "kiss" is, unfortunately deadly in most cases. Currently, few sparse data are available in literature concerning the origins of TNBC. Vasculogenic mimicry detected in TNBCs, seems to be determined by a population of CD133+ cells and may be stimulated by different pharmacological agents such sunitinib. Despite the fact that TNBCs do not usually metastasize through the lymphatic pathways, TNBCs may be characterized by lymphatic invasion and by an increased lymphatic microvascular density. If TNBCs treatment depends on the molecular profile of the tumor, the same statement may be postulated for TNBCs metastasis. Whether metastases have a similar phenotype as the primary tumor remains an enigma. Therefore, the question: 'Could TNBC be subject to a standardized, unanimously accepted therapeutic strategy or is it strictly subclass-dependent?' remains to be further investigated.
三阴性乳腺癌（TNBC）是最具争议性的女性恶性肿瘤之一，本文对此进行了批判性综述，重点关注对临床实践有用的数据，或有助于改善治疗及患者生存率的数据。TNBC “青睐” 年轻女性，不幸的是，在大多数情况下其 “杀伤力” 极大。目前，关于TNBC起源的文献资料稀少。在TNBC中检测到的血管生成拟态似乎由一群CD133 +细胞决定，并且可能受到不同药物制剂（如舒尼替尼）的刺激。尽管TNBC通常不会通过淋巴途径转移，但TNBC的特征可能是存在淋巴浸润以及淋巴管微血管密度增加。如果TNBC的治疗取决于肿瘤的分子特征，那么TNBC转移也可能遵循同样的规律。转移灶是否与原发肿瘤具有相似的表型仍是一个谜。因此，“TNBC是否可以采用标准化的、被一致认可的治疗策略，还是它严格依赖于亚类分类？” 这个问题仍有待进一步研究。
