米非司酮用于堕胎会增加患子宫平滑肌瘤的风险。
The use of mifepristone in abortion associated with an increased risk of uterine leiomyomas.
作者信息
Shen Qi, Shu Li, Luo Hui, Hu Xiaoli, Zhu Xueqiong
机构信息
Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
出版信息
Medicine (Baltimore). 2017 Apr;96(17):e6680. doi: 10.1097/MD.0000000000006680.
To investigate the association between widespread use of mifepristone in abortions and risk of uterine leiomyomas.We conducted a case-control study of 305 patients with uterine leiomyomas between January 2011 and July 2012; 311 women with ordinary vaginitis were selected as controls during the same period. Data were collected by questionnaires (including past history, life history, menstruation history, reproductive history, abortion history, the use of mifepristone, and uterine leiomyomas risk factors) and calculated by univariate and multivariate conditional logistic regression analyses; odds ratios and its 95% confidence interval were calculated to estimate the risk for uterine leiomyomas.Abortion with mifepristone was one of the risk factors for uterine leiomyomas, and the risk increased with increasing frequency of mifepristone use. Family history of uterine leiomyomas, body mass index, age at menarche, number of full-term delivery, and medical abortion history were also correlated with uterine leiomyomas.The use of mifepristone in abortion will increase the risk to develop uterine leiomyomas.
探讨米非司酮在堕胎中的广泛使用与子宫肌瘤风险之间的关联。我们在2011年1月至2012年7月期间对305例子宫肌瘤患者进行了一项病例对照研究；同期选取311例普通阴道炎女性作为对照。通过问卷调查（包括既往史、生活史、月经史、生殖史、堕胎史、米非司酮使用情况以及子宫肌瘤危险因素）收集数据，并通过单因素和多因素条件逻辑回归分析进行计算；计算比值比及其95%置信区间以估计子宫肌瘤风险。使用米非司酮堕胎是子宫肌瘤的危险因素之一，且风险随米非司酮使用频率增加而升高。子宫肌瘤家族史、体重指数、初潮年龄、足月分娩次数和药物流产史也与子宫肌瘤相关。堕胎时使用米非司酮会增加患子宫肌瘤的风险。
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