a Department of Food and Nutrition , Sookmyung Women's University , Seoul , Republic of Korea.
b Department of Food and Nutrition , College of Human Ecology, Seoul National University , Seoul , Republic of Korea.
Curr Med Res Opin. 2018 Nov;34(11):1913-1919. doi: 10.1080/03007995.2018.1462783. Epub 2018 May 9.
This study examined the associations between anthropometric measures and uterine leiomyomas.
This study included a total of 5,062 women (median age of 35.5 years) who had experienced pregnancy and, of these women, 210 reported a diagnosis of uterine leiomyomas within the past 2 years prior to baseline in the Korea Nurses' Health Study. Participants were asked about their anthropometric factors. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using logistic regression models.
Mean body mass index (BMI) was 21.8 kg/m among non-cases. An increase in weight from the age of 18 years to the present was associated with increased risk of uterine leiomyomas (p for trend = .002); compared to women whose weight remained stable, the multivariate ORs (95% CIs) were 1.84 (1.22-2.76) for weight gain of 5-10 kg and 2.00 (1.25-3.20) for weight gain of more than 10 kg since age 18. A similar pattern was observed when the analysis was limited to women with a BMI of 18.5-25 kg/m. Current weight was associated with higher odds of uterine leiomyomas. No associations were found for body size in childhood or in adolescence, weight at age 18, current BMI, or current body size.
Weight gain in adulthood was associated with increased risk of uterine leiomyomas in Korean women, even in those with normal weight.
本研究探讨了人体测量学指标与子宫肌瘤之间的关联。
本研究共纳入 5062 名女性（中位年龄 35.5 岁），这些女性均有妊娠史，其中 210 名女性在基线前 2 年内报告了子宫肌瘤诊断。研究对象被问及他们的人体测量因素。使用逻辑回归模型计算比值比（ORs）和 95%置信区间（95% CIs）。
非病例组的平均体重指数（BMI）为 21.8kg/m2。从 18 岁到现在体重的增加与子宫肌瘤的风险增加相关（趋势 p=.002）；与体重保持稳定的女性相比，体重增加 5-10kg 和体重增加超过 10kg 的多变量 OR（95% CI）分别为 1.84（1.22-2.76）和 2.00（1.25-3.20）。当分析仅限于 BMI 为 18.5-25kg/m2 的女性时，观察到类似的模式。目前的体重与子宫肌瘤的几率更高有关。在儿童期或青春期、18 岁时的体重、目前的 BMI 或目前的体型方面，没有发现身体大小的关联。
韩国女性成年后体重增加与子宫肌瘤风险增加相关，即使在体重正常的女性中也是如此。
