Kang Seung-Gul, Na Kyoung-Sae, Choi Jae-Won, Kim Jeong-Hee, Son Young-Don, Lee Yu Jin
Department of Psychiatry, Gil Medical Center, Gachon University, School of Medicine, Incheon, Republic of Korea.
Department of Neuropsychiatry, Eulji University School of Medicine, Eulji General Hospital, Seoul, Republic of Korea.
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 3;77:222-227. doi: 10.1016/j.pnpbp.2017.04.029. Epub 2017 Apr 23.
In this study, we investigated the difference in resting-state functional connectivity (RSFC) of the amygdala between suicide attempters and non-suicide attempters with major depressive disorder (MDD) using functional magnetic resonance imaging (fMRI). This study included 19 suicide attempters with MDD and 19 non-suicide attempters with MDD. RSFC was compared between the two groups and the regression analyses were conducted to identify the correlation between RSFC and Scale for Suicide Ideation (SSI) scores in the suicide attempt group. Statistical significance was set at p-value (uncorrected) <0.005 with k≥28 voxels. Compared with non-suicide attempters, suicide attempters showed significantly increased RSFC of the left amygdala with the right insula and left superior orbitofrontal area, and increased RSFC of the right amygdala with the left middle temporal area. The regression analysis showed a significant correlation between the SSI total score and RSFC of the right amygdala with the right parahippocampal area in the suicide attempt group. The present RSFC findings provide evidence of a functional neural basis and will help reveal the pathophysiology underlying suicidality in subjects with MDD.
在本研究中，我们使用功能磁共振成像（fMRI）调查了重度抑郁症（MDD）自杀未遂者与非自杀未遂者杏仁核静息态功能连接（RSFC）的差异。本研究纳入了19名MDD自杀未遂者和19名MDD非自杀未遂者。比较了两组之间的RSFC，并进行回归分析以确定自杀未遂组中RSFC与自杀意念量表（SSI）评分之间的相关性。统计学显著性设定为p值（未校正）<0.005且k≥28体素。与非自杀未遂者相比，自杀未遂者左侧杏仁核与右侧脑岛及左侧眶额上区的RSFC显著增加，右侧杏仁核与左侧颞中区的RSFC增加。回归分析显示，自杀未遂组中SSI总分与右侧杏仁核与右侧海马旁区域的RSFC之间存在显著相关性。目前的RSFC研究结果为功能性神经基础提供了证据，并将有助于揭示MDD患者自杀行为背后的病理生理学机制。
