Ioannides Zara A, Steyn Frederik J, Henderson Robert D, Mccombe Pamela A, Ngo Shyuan T
a The University of Queensland Centre for Clinical Research, The University of Queensland , Herston , Australia.
b Department of Neurology , Royal Brisbane & Women's Hospital , Herston , Australia.
Amyotroph Lateral Scler Frontotemporal Degener. 2017 Nov;18(7-8):486-491. doi: 10.1080/21678421.2017.1317811. Epub 2017 Apr 27.
Anthropometric measurements including body mass index (BMI) and body adiposity index (BAI) are widely employed as indicators of fat mass (FM). Metabolic abnormalities in amyotrophic lateral sclerosis (ALS) impact disease progression, therefore assessment of FM informs care. The aim of this study was to determine whether BMI and BAI are accurate predictors of FM in ALS. Methodology and main findings: BMI, BAI and percentage FM (determined by air displacement plethysmography; FM-ADP) were measured in control (n = 35) and ALS (n = 44) participants. While BMI and BAI correlated significantly with FM-ADP, neither index provided an accurate estimate of FM. In longitudinally assessed ALS participants (n = 29; ∼six-month repeat assessment interval), although a change in BMI (r = 0.62 r = 0.79 p < 0.01) and BAI (r = 0.20 r = 0.44, p = 0.02) correlated with a change in FM-ADP, the anthropometric measures did not consistently reflect increases or decreases observed in FM-ADP.
CONCLUSIONS/SIGNIFICANCE: Using FM-ADP as the standard, this study suggests that BMI and BAI are not accurate measures of FM in ALS. Furthermore, longitudinal assessments indicate that changes in BMI and BAI do not consistently reflect true changes of FM in ALS.
包括体重指数（BMI）和身体脂肪指数（BAI）在内的人体测量指标被广泛用作脂肪量（FM）的指标。肌萎缩侧索硬化症（ALS）中的代谢异常会影响疾病进展，因此对FM的评估有助于护理。本研究的目的是确定BMI和BAI是否是ALS中FM的准确预测指标。方法和主要发现：在对照组（n = 35）和ALS组（n = 44）参与者中测量了BMI、BAI和FM百分比（通过空气置换体积描记法测定；FM-ADP）。虽然BMI和BAI与FM-ADP显著相关，但这两个指标均未提供对FM的准确估计。在纵向评估的ALS参与者中（n = 29；重复评估间隔约为6个月），尽管BMI的变化（r = 0.62，r = 0.79，p < 0.01）和BAI的变化（r = 0.20，r = 0.44，p = 0.02）与FM-ADP的变化相关，但人体测量指标并未始终反映出FM-ADP中观察到的增加或减少。
结论/意义：以FM-ADP作为标准，本研究表明BMI和BAI不是ALS中FM的准确测量指标。此外，纵向评估表明，BMI和BAI的变化并未始终反映ALS中FM的真实变化。
