Moreno Ayala Mariela A, Gottardo Maria Florencia, Asad Antonela S, Zuccato Camila, Nicola Alejandro, Seilicovich Adriana, Candolfi Marianela
a Instituto de Investigaciones Biomédicas (INBIOMED-CONICET/UBA), Facultad de Medicina , Universidad de Buenos Aires , Buenos Aires , Argentina.
Expert Opin Biol Ther. 2017 Jul;17(7):797-812. doi: 10.1080/14712598.2017.1324566. Epub 2017 May 8.
Breast cancer is the most common cancer as well as the first cause of death by cancer in women worldwide. Although routine treatment improves the outcome of early stage breast cancer patients, there is no effective therapy for the disseminated disease. Immunotherapy has emerged as a powerful therapeutic strategy for the treatment of many cancers. Although traditionally conceived as a non-immunogenic tumor, breast cancer is now considered a potential target for immunotherapy. Areas covered: In this review, the authors discuss different immunotherapeutic strategies that are currently being tested for the treatment of breast cancer: These strategies include: (i) blockade of immunological checkpoints, (ii) antitumor vaccines, (iii) regulatory T cell blockade, (iv) adoptive T cell transfer therapy, (iv) adoptive immunotherapy with monoclonal antibodies, and (v) combination of immunotherapy with chemotherapy. Expert opinion: A growing body of evidence indicates that immunotherapeutic strategies can benefit a larger cohort of breast cancer patients than hitherto anticipated. Since breast tumors entail multiple mechanisms to impair antitumor immunity, the immunological characterization of individual tumors and the selection of suitable combinations of chemotherapeutic and immunotherapeutic approaches are required to achieve significant clinical benefit in these patients.
乳腺癌是全球女性中最常见的癌症，也是癌症死亡的首要原因。尽管常规治疗改善了早期乳腺癌患者的治疗结果，但对于转移性疾病尚无有效的治疗方法。免疫疗法已成为治疗多种癌症的有力治疗策略。尽管乳腺癌传统上被认为是一种非免疫原性肿瘤，但现在被认为是免疫疗法的潜在靶点。涵盖领域：在本综述中，作者讨论了目前正在测试用于治疗乳腺癌的不同免疫治疗策略：这些策略包括：（i）免疫检查点阻断，（ii）抗肿瘤疫苗，（iii）调节性T细胞阻断，（iv）过继性T细胞转移疗法，（iv）单克隆抗体过继性免疫疗法，以及（v）免疫疗法与化疗的联合应用。专家观点：越来越多的证据表明，免疫治疗策略能够使比迄今预期更多的乳腺癌患者受益。由于乳腺肿瘤存在多种损害抗肿瘤免疫的机制，因此需要对个体肿瘤进行免疫学特征分析，并选择合适的化疗和免疫治疗方法组合，才能使这些患者获得显著的临床益处。
