[不同剂量重组人粒细胞集落刺激因子对血液系统恶性肿瘤患者化疗后白细胞减少持续时间及白细胞水平的影响]

[Effects of Different Dosages of rhG-CSF on Duration of Aleucocytosis and Leukocytes Level after Chemotherapy of Patients with Hematologic Malignancies].

作者信息

Gu Yue-Li, Xiao Xi-Chun, Yang Shuo

机构信息

Department of Haematology, The First People's Hospital of Shangqiu, Shangqiu 476100, Henan Province, China. E-mail:

Department of Haematology, The First People's Hospital of Shangqiu, Shangqiu 476100, Henan Province, China.

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Apr;25(2):398-402. doi: 10.7534/j.issn.1009-2137.2017.02.016.

DOI:10.7534/j.issn.1009-2137.2017.02.016

PMID:28446282

Abstract

OBJECTIVE

To compare the effects of different dosages of rhG-CSF on duration of aleucocytosis and white blood cell counts after chemotherapy of patients with hematologic malignancies.

METHODS

Ninety patients in our hospital from December 2011 to June 2016 were chosen as study objects, and all of them were divided into 3 groups: group A (rhG-CSF 200 µg/m), group B(rhG-CSF 300 µg/m) and group C(rhG-CSF 400 µg/m); 30 patients from January 2004 to January 2007 were chosen as control(control group). The WBC and its duration, WBC and its timepoint were compared among different groups. The infection rate, incidence of side reactions and total amount of rhG-CSF used in different groups were compared.

RESULTS

In control group, WBC was(1.30±0.11)×10/L, its duration was (3.2±0.7)d, WBC was(5.14±0.41)×10/L, and its time point was (26.1±1.8)d; these in group A were (3.14±0.23)×10/L,(2.7±1.0)d, (10.08±0.69)×10/L and (14.9±1.8)d respectively; these in group B were (3.11±0.32)×10/L, (0.9±0.5)d, (10.17±0.75)×10/L and(10.7±1.5)d respectively; these in group C were (3.15±0.30)×10/L,(0.5±0.3)d, (11.95±0.86)×10/L and (10.6±1.5)d, respectively. Compared with control group, the WBC and WBC were both increased significantly, the duration of WBC was shortened and the timepoint of WBC was moved up(P<0.05). The infection rate of group C (3.33%(1/30)) was significantly lower than that of control group(33.33%(10/30))(P<0.05), total used amount of rhG-CSF and incidence of side reactions were not statistically different among group A,B,C(P>0.05).

CONCLUSION

Compared with low dosage of rhG-CSF, medium/high dosage of rhG-CSF can help to shorten duration of a leukocytosis after chemotherapy of patients.

摘要

目的

比较不同剂量重组人粒细胞集落刺激因子（rhG-CSF）对血液系统恶性肿瘤患者化疗后白细胞减少持续时间及白细胞计数的影响。

方法

选取2011年12月至2016年6月我院90例患者作为研究对象，将其分为3组：A组（rhG-CSF 200μg/m）、B组（rhG-CSF 300μg/m）和C组（rhG-CSF 400μg/m）；选取2004年1月至2007年1月30例患者作为对照组。比较不同组间白细胞及其持续时间、白细胞及其时间点。比较不同组间感染率、不良反应发生率及rhG-CSF使用总量。

结果

对照组白细胞为（1.30±0.11）×10⁹/L，其持续时间为（3.2±0.7）天，白细胞为（5.14±0.41）×10⁹/L，其时间点为（26.1±1.8）天；A组分别为（3.14±0.23）×10⁹/L、（2.7±1.0）天、（10.08±0.69）×10⁹/L和（14.9±1.8）天；B组分别为（3.11±0.32）×10⁹/L、（0.9±0.5）天、（10.17±0.75）×10⁹/L和（10.7±1.5）天；C组分别为（3.15±0.30）×10⁹/L、（0.5±0.3）天、（11.95±0.86）×10⁹/L和（10.6±1.5）天。与对照组比较，白细胞及白细胞均显著升高，白细胞持续时间缩短，白细胞时间点提前（P<0.05）。C组感染率（3.33%（1/30））显著低于对照组（33.33%（10/30））（P<0.05），A、B、C组间rhG-CSF使用总量及不良反应发生率差异无统计学意义（P>0.05）。