促炎饮食与中年女性患高血压风险增加有关。

A pro-inflammatory diet is associated with increased risk of developing hypertension among middle-aged women.

作者信息

Vissers L E T, Waller M, van der Schouw Y T, Hébert J R, Shivappa N, Schoenaker D A J M, Mishra G D

机构信息

The University of Queensland, School of Public Health, Brisbane, Australia; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

The University of Queensland, School of Public Health, Brisbane, Australia.

出版信息

Nutr Metab Cardiovasc Dis. 2017 Jun;27(6):564-570. doi: 10.1016/j.numecd.2017.03.005. Epub 2017 Mar 29.

DOI:10.1016/j.numecd.2017.03.005

PMID:28446366

Abstract

BACKGROUND AND AIMS

A pro-inflammatory diet is thought to lead to hypertension through oxidative stress and vessel wall inflammation. We therefore investigated the association between the dietary inflammatory index (DII) and developing hypertension in a population-based cohort of middle-aged women.

METHODS AND RESULTS

The Australian Longitudinal Study on Women's Health included 7169 Australian women, aged 52 years (SD 1 year) at baseline in 2001, who were followed up through 4 surveys until 2013. The DII, a literature-derived dietary index that has been validated against several inflammatory markers, was calculated based on data collected via a validated food-frequency questionnaire administered at baseline. Hypertension was defined as new onset of doctor-diagnosed hypertension, ascertained through self-report between 2001 and 2013. Generalised Estimating Equation analyses were used to investigate the association between the DII and incident hypertension. The analyses were adjusted for demographic and hypertension risk factors. During 12-years follow-up we identified 1680 incident cases of hypertension. A more pro-inflammatory diet was associated with higher risk of hypertension in dichotomised analyses with an OR of 1.24, 95% CI: 1.06-1.45.

CONCLUSION

A pro-inflammatory diet might lead to a higher risk of developing hypertension. These results need to be replicated in other studies.

摘要

背景与目的

促炎饮食被认为会通过氧化应激和血管壁炎症导致高血压。因此，我们在一个基于人群的中年女性队列中研究了饮食炎症指数（DII）与高血压发病之间的关联。

方法与结果

澳大利亚妇女健康纵向研究纳入了7169名澳大利亚女性，她们在2001年基线时年龄为52岁（标准差1岁），通过4次调查进行随访直至2013年。DII是一种基于文献得出的饮食指数，已根据多种炎症标志物进行了验证，它是根据在基线时通过一份经过验证的食物频率问卷收集的数据计算得出的。高血压定义为2001年至2013年期间通过自我报告确定的新诊断的医生确诊高血压。使用广义估计方程分析来研究DII与高血压发病之间的关联。分析对人口统计学和高血压风险因素进行了调整。在12年的随访期间，我们确定了1680例高血压发病病例。在二分法分析中，促炎程度更高的饮食与高血压风险较高相关，比值比为1.24，95%置信区间：1.06 - 1.45。