National Research Council,, Neuroscience Institute, Aging Branch, Via Giustiniani, 2, 35128, Padova, Italy.
Ambulatory of Nutrition, IRCCS "S. de Bellis", National Institute of Gastroenterology-Research Hospital, Castellana Grotte, Bari, Italy.
Osteoporos Int. 2018 Jan;29(1):143-151. doi: 10.1007/s00198-017-4251-5. Epub 2017 Oct 10.
In this study, during 8 years of follow-up, we reported that higher dietary inflammatory index values were associated with a higher risk of incident fractures in women, but not in men, after adjusting for potential confounders.
Inflammation is a key risk factor for many adverse outcomes in older people. While diet is a potential source of inflammation, little is known about the impact of inflammatory diet on fractures. Thus, we investigated whether higher Dietary Inflammatory Index (DII)™ ® scores are associated with fractures in a cohort of North American people.
This longitudinal study with a follow-up of 8 years included 3648 participants (1577 males and 2071 females; mean age = 60.6 years) with/at risk of knee osteoarthritis participating with in the Osteoarthritis Initiative. DII scores were calculated using the validated Block Brief 2000 Food Frequency Questionnaire, categorized into sex-specific quintiles. Information on fractures was obtained through self-reported history of fractures at hip, spine, and forearm. The relationship between baseline DII score and incident fracture was assessed through a Cox's regression analysis, adjusted for potential baseline confounders, and reported as hazard ratios (HRs).
During 8 years of follow-up, 560 individuals developed fractures (15.4%). Adjusting for 10 potential confounders, women in the highest DII score quintile (i.e., most pro-inflammatory diet) had a significantly higher risk for fractures (HR = 1.46; 95% CI = 1.02-2.11) compared to women in the lowest quintile. An increase in one standard deviation of DII scores significantly predicted fracture onset in women (adjusted HR = 1.14; 95% CI = 1.02-1.27). The association between DII score and fractures was not significant among men or in the sample as whole.
Pro-inflammatory diet is associated with a higher incidence of fractures in women but not men.
本研究在 8 年的随访期间报告称，在调整了潜在混杂因素后，较高的膳食炎症指数值与女性而非男性的骨折风险增加相关。
炎症是老年人许多不良后果的关键风险因素。虽然饮食是炎症的潜在来源，但人们对炎症饮食对骨折的影响知之甚少。因此，我们研究了在北美人群中，较高的膳食炎症指数（DII）评分是否与骨折有关。
这项具有 8 年随访的纵向研究纳入了 3648 名（男性 1577 名，女性 2071 名；平均年龄 60.6 岁）有/有膝关节骨关节炎风险的参与者，他们参加了骨关节炎倡议。DII 评分使用经过验证的 Block Brief 2000 食物频率问卷计算，并按性别分为五分位数。骨折信息通过自我报告的髋部、脊柱和前臂骨折史获得。通过 Cox 回归分析评估基线 DII 评分与新发骨折之间的关系，调整了潜在的基线混杂因素，并报告为风险比（HR）。
在 8 年的随访期间，560 人发生了骨折（15.4%）。调整了 10 个潜在混杂因素后，DII 评分最高五分位数（即最促炎饮食）的女性骨折风险显著高于最低五分位数的女性（HR=1.46；95%CI=1.02-2.11）。DII 评分增加一个标准差与女性骨折发病显著相关（调整 HR=1.14；95%CI=1.02-1.27）。在男性或整体样本中，DII 评分与骨折之间的关联不显著。
促炎饮食与女性而非男性骨折发生率增加相关。
