Li Ning, Chen Hong-Wu, Zhou Xin-Hua, Liang Li
1Department of Neonatal Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 3Department of Neonatal Medicine, Children's Hospital of Dongguan, Dongguan 523325, China. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2016 Apr 20;37(4):528-532. doi: 10.3969/j.issn.1673-4254.2017.04.18.
We reviewed the data of 38 neonates who died of respiratory failure. Paraffin sections of the autopsy lung samples were examined with HE staining or immunolabeling for CD34, CD68 and CK to observe the development of the pulmonary vessels and detect potential pulmonary vascular diseases (PVDs). Five cases were identified to have PVDs, including pulmonary hypertensive vascular remodeling in 3 cases and alveolar capillary dysplasia in 2 cases. The result indicated that PVD was one of the important reasons for respiratory failure in these neonates.
我们回顾了38例死于呼吸衰竭的新生儿的数据。对尸检肺样本的石蜡切片进行苏木精-伊红（HE）染色或针对CD34、CD68和细胞角蛋白（CK）的免疫标记检查，以观察肺血管的发育情况并检测潜在的肺血管疾病（PVD）。确定有5例存在PVD，其中3例为肺动脉高压性血管重塑，2例为肺泡毛细血管发育异常。结果表明，PVD是这些新生儿呼吸衰竭重要原因之一。
