Department of Child Health, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Department of Endocrinology and Diabetes, Royal Hospital for Sick Children, Edinburgh, Scotland.
Arch Dis Child. 2017 Oct;102(10):975-980. doi: 10.1136/archdischild-2016-311372. Epub 2017 Apr 26.
Pubertal induction in girls with ovarian insufficiency aims to mimic normal puberty, a highly complex process. Here we amalgamate the sparse global evidence and propose three options for pubertal induction regimens including oral ethinyloestradiol, and oral and transdermal 17β-oestradiol. The introduction of progestogens is discussed and the transition to hormone supplementation for adult women. The merits and disadvantages of the different options are detailed. The available evidence indicates that transdermal 17β-oestradiol has the most favourable efficacy, safety and cost profile but randomised controlled trials are urgently required to determine which regimen provides the best clinical outcomes.
卵巢功能不全的女孩的青春期诱导旨在模拟正常的青春期，这是一个高度复杂的过程。在这里，我们综合了全球稀少的证据，并提出了三种青春期诱导方案，包括口服炔雌醇和口服及经皮 17β-雌二醇。我们讨论了孕激素的引入以及向成年女性的激素补充过渡。详细说明了不同方案的优缺点。现有证据表明，经皮 17β-雌二醇具有最佳的疗效、安全性和成本效益，但迫切需要进行随机对照试验来确定哪种方案提供最佳的临床结果。
