在慢性淋巴细胞白血病（CLL）中，合并症和复杂核型与较差的预后相关，且独立于CLL国际预后指数（CLL-IPI）。 - Suppr

In CLL, comorbidities and the complex karyotype are associated with an inferior outcome independently of CLL-IPI.

作者信息

Rigolin Gian Matteo, Cavallari Maurizio, Quaglia Francesca Maria, Formigaro Luca, Lista Enrico, Urso Antonio, Guardalben Emanuele, Liberatore Carmine, Faraci Danilo, Saccenti Elena, Bassi Cristian, Lupini Laura, Bardi Maria Antonella, Volta Eleonora, Tammiso Elisa, Melandri Aurora, Negrini Massimo, Cavazzini Francesco, Cuneo Antonio

机构信息

Sezione Ematologia, Dipartimento di Scienze Mediche, Azienda Ospedaliero-Universitaria, Arcispedale S. Anna.

Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, and.

出版信息

Blood. 2017 Jun 29;129(26):3495-3498. doi: 10.1182/blood-2017-03-772285. Epub 2017 Apr 26.

DOI:10.1182/blood-2017-03-772285

PMID:28446433

Abstract

摘要

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In CLL, comorbidities and the complex karyotype are associated with an inferior outcome independently of CLL-IPI.在慢性淋巴细胞白血病（CLL）中，合并症和复杂核型与较差的预后相关，且独立于CLL国际预后指数（CLL-IPI）。

Blood. 2017 Jun 29;129(26):3495-3498. doi: 10.1182/blood-2017-03-772285. Epub 2017 Apr 26.

Evaluation of the CLL-IPI in relapsed and refractory chronic lymphocytic leukemia in idelalisib phase-3 trials.在伊布替尼 3 期临床试验中评估复发/难治性慢性淋巴细胞白血病的 CLL-IPI。

Leuk Lymphoma. 2019 Jun;60(6):1438-1446. doi: 10.1080/10428194.2018.1540782. Epub 2018 Nov 8.

Changes in clinical stage identify patients with CLL and different outcome within iwCLL partial response: RESONATE study.临床分期的变化可识别慢性淋巴细胞白血病患者以及国际慢性淋巴细胞白血病研讨会（iwCLL）部分缓解情况下不同的预后：RESONATE研究。

Br J Haematol. 2019 Apr;185(1):148-150. doi: 10.1111/bjh.15397. Epub 2018 May 31.

Predicting survival in chronic lymphocytic leukemia.预测慢性淋巴细胞白血病患者的生存情况。

Expert Rev Anticancer Ther. 2012 Mar;12(3):393-403. doi: 10.1586/era.12.2.

Prognostic factors in chronic lymphocytic leukaemia.慢性淋巴细胞白血病的预后因素

Haematologica. 1999 Jun;84 Suppl EHA-4:96-7.

Diabetes Mellitus Is Associated with Inferior Prognosis in Patients with Chronic Lymphocytic Leukemia: A Propensity Score-Matched Analysis.糖尿病与慢性淋巴细胞白血病患者预后不良相关：一项倾向评分匹配分析。

Cancer Res Treat. 2020 Jan;52(1):189-206. doi: 10.4143/crt.2019.122. Epub 2019 Jul 1.

Serum beta(2)-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma.血清β2微球蛋白和血清胸苷激酶是慢性淋巴细胞白血病和免疫细胞瘤无进展生存期的独立预测指标。

Leuk Lymphoma. 1996 Aug;22(5-6):439-47. doi: 10.3109/10428199609054782.

p53 Aberrations do not predict individual response to fludarabine in patients with B-cell chronic lymphocytic leukaemia in advanced stages Rai III/IV.在晚期Rai III/IV期B细胞慢性淋巴细胞白血病患者中，p53异常不能预测对氟达拉滨的个体反应。

Br J Haematol. 2005 Apr;129(1):53-9. doi: 10.1111/j.1365-2141.2005.05405.x.

Integrated CLL Scoring System, a New and Simple Index to Predict Time to Treatment and Overall Survival in Patients With Chronic Lymphocytic Leukemia.综合慢性淋巴细胞白血病评分系统，一种预测慢性淋巴细胞白血病患者治疗时间和总生存期的新的简易指标。

Clin Lymphoma Myeloma Leuk. 2015 Oct;15(10):612-20.e1-5. doi: 10.1016/j.clml.2015.06.001. Epub 2015 Jun 20.

Comparative assessment of prognostic models in chronic lymphocytic leukemia: evaluation in Indian cohort.比较慢性淋巴细胞白血病预后模型的评估：印度队列的评估。

Ann Hematol. 2019 Feb;98(2):437-443. doi: 10.1007/s00277-018-3525-0. Epub 2018 Oct 18.

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In CLL, comorbidities and the complex karyotype are associated with an inferior outcome independently of CLL-IPI.

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