Cartagena N, Cabello-Inchausti B, Willis I, Poppiti R
Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach.
Hum Pathol. 1988 Oct;19(10):1239-43. doi: 10.1016/s0046-8177(88)80159-x.
Primary clear cell tumors of the breast are rare neoplasms. Traditionally, their differential diagnosis has included lipid-rich, glycogen-rich, and secretory carcinomas of the breast. Although clear cell myoepithelial tumors of the salivary gland and skin have been reported, a primary clear cell myoepithelial carcinoma of the breast has not been previously described. We report a case of clear cell myoepithelial neoplasm of the breast showing an infiltrative histologic growth pattern highly suggestive of carcinoma. Electron microscopy showed evidence of myoepithelial differentiation manifested by cytoplasmic microfilaments with randomly dispersed fusiform densities in conjunction with specialized membrane junctions and remnants of basal membrane. Immunohistologically, the tumor cells were positive for actin, keratin, and S-100 protein. This tumor should be included in the differential diagnosis of the clear cell neoplasms of the breast.
乳腺原发性透明细胞肿瘤是罕见的肿瘤。传统上，其鉴别诊断包括乳腺富含脂质、富含糖原和分泌性癌。尽管已有唾液腺和皮肤透明细胞肌上皮瘤的报道，但乳腺原发性透明细胞肌上皮癌此前尚未见描述。我们报告1例乳腺透明细胞肌上皮肿瘤，其组织学生长模式呈浸润性，高度提示为癌。电子显微镜显示有肌上皮分化的证据，表现为细胞质微丝，伴有随机分布的梭形致密物，以及特殊的膜连接和基底膜残余。免疫组织化学检查显示，肿瘤细胞肌动蛋白、角蛋白和S-100蛋白呈阳性。该肿瘤应列入乳腺透明细胞肿瘤的鉴别诊断。
