开创性的EBF2重塑棕色脂肪染色质景观。
Pioneering EBF2 remodels the brown fat chromatin landscape.
作者信息
Wang Jiexin, Tontonoz Peter
机构信息
Department of Pathology and Laboratory Medicine and Molecular Biology Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90272, USA.
出版信息
Genes Dev. 2017 Apr 1;31(7):632-633. doi: 10.1101/gad.299644.117.
Abstract
In this issue of , Shapira and colleagues (pp. 660-673) outline mechanisms by which the brown fat transcription factor early B-cell factor 2 (EBF2) selectively activates brown lineage-specific gene expression. The investigators show that EBF2 interacts with and recruits a tissue-specific BAF chromatin remodeling complex to brown fat gene enhancers, thereby regulating chromatin accessibility. Their findings provide important insight into epigenetic regulation of adipocyte fate and thermogenic gene expression.
摘要
在本期杂志中，沙皮拉及其同事（第660 - 673页）概述了棕色脂肪转录因子早期B细胞因子2（EBF2）选择性激活棕色脂肪谱系特异性基因表达的机制。研究人员表明，EBF2与一种组织特异性BAF染色质重塑复合物相互作用，并将其招募至棕色脂肪基因增强子，从而调节染色质的可及性。他们的发现为脂肪细胞命运和产热基因表达的表观遗传调控提供了重要见解。
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本文引用的文献
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Genes Dev. 2017 Apr 1;31(7):660-673. doi: 10.1101/gad.294405.116. Epub 2017 Apr 20.
2
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.棕色和米色脂肪细胞命运与功能的转录和表观遗传调控。
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EBF2 promotes the recruitment of beige adipocytes in white adipose tissue.EBF2促进白色脂肪组织中米色脂肪细胞的募集。
Mol Metab. 2015 Nov 14;5(1):57-65. doi: 10.1016/j.molmet.2015.11.001. eCollection 2016 Jan.
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