Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.
Materials Chemistry Research Centre, UCL Department of Chemistry, London, WC1H 0AJ, UK.
Sci Rep. 2017 Apr 26;7(1):1208. doi: 10.1038/s41598-017-01375-2.
A miniature all-optical ultrasound imaging system is presented that generates three-dimensional images using a stationary, real acoustic source aperture. Discrete acoustic sources were sequentially addressed by scanning a focussed optical beam across the proximal end of a coherent fibre bundle; high-frequency ultrasound (156% fractional bandwidth centred around 13.5 MHz) was generated photoacoustically in the corresponding regions of an optically absorbing coating deposited at the distal end. Paired with a single fibre-optic ultrasound detector, the imaging probe (3.5 mm outer diameter) achieved high on-axis resolutions of 97 μm, 179 μm and 110 μm in the x, y and z directions, respectively. Furthermore, the optical scan pattern, and thus the acoustic source array geometry, was readily reconfigured. Implementing four different array geometries revealed a strong dependency of the image quality on the source location pattern. Thus, by employing optical technology, a miniature ultrasound probe was fabricated that allows for arbitrary source array geometries, which is suitable for three-dimensional endoscopic and laparoscopic imaging, as was demonstrated on ex vivo porcine cardiac tissue.
提出了一种微型全光学超声成像系统，该系统使用固定的真实声源孔径生成三维图像。通过将聚焦光束在相干光纤束的近端扫描，离散的声源被依次寻址；在远端沉积的光吸收涂层的相应区域中，光声产生高频超声（13.5MHz 左右的 156%分数带宽）。与单个光纤超声探测器配合使用，成像探头（外径 3.5mm）在 x、y 和 z 方向上分别实现了 97μm、179μm 和 110μm 的高轴向分辨率。此外，光学扫描模式，从而声源远阵列几何形状，很容易重新配置。实现四种不同的阵列几何形状揭示了图像质量对源位置模式的强烈依赖性。因此，通过采用光学技术，制造了一种微型超声探头，该探头允许任意的源阵列几何形状，非常适合三维内窥镜和腹腔镜成像，在离体猪心脏组织上得到了验证。
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