Colchester Richard J, Zhang Edward Z, Mosse Charles A, Beard Paul C, Papakonstantinou Ioannis, Desjardins Adrien E
Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London, WC1E 6BT, UK.
Department of Electronic and Electrical Engineering, University College London, Gower Street, London, WC1E 6BT, UK.
Biomed Opt Express. 2015 Mar 26;6(4):1502-11. doi: 10.1364/BOE.6.001502. eCollection 2015 Apr 1.
An all-optical ultrasound probe for vascular tissue imaging was developed. Ultrasound was generated by pulsed laser illumination of a functionalized carbon nanotube composite coating on the end face of an optical fiber. Ultrasound was detected with a Fabry-Pérot (FP) cavity on the end face of an adjacent optical fiber. The probe diameter was < 0.84 mm and had an ultrasound bandwidth of ~20 MHz. The probe was translated across the tissue sample to create a virtual linear array of ultrasound transmit/receive elements. At a depth of 3.5 mm, the axial resolution was 64 µm and the lateral resolution was 88 µm, as measured with a carbon fiber target. Vascular tissues from swine were imaged ex vivo and good correspondence to histology was observed.
开发了一种用于血管组织成像的全光学超声探头。通过对光纤端面的功能化碳纳米管复合涂层进行脉冲激光照射来产生超声波。利用相邻光纤端面上的法布里-珀罗（FP）腔来检测超声波。探头直径小于0.84毫米，超声带宽约为20兆赫。探头在组织样本上平移，以创建超声发射/接收元件的虚拟线性阵列。用碳纤维靶标测量，在3.5毫米深度处，轴向分辨率为64微米，横向分辨率为88微米。对猪的血管组织进行了离体成像，并观察到与组织学的良好对应关系。
