Shamsaei Nabi, Erfani Soheila, Fereidoni Masoud, Shahbazi Ali
Department of Physical Education, Faculty of Literature and Humanities, Ilam University, Ilam, Iran.
Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
Basic Clin Neurosci. 2017 Jan;8(1):77-84. doi: 10.15412/J.BCN.03080110.
Cerebral ischemia and reperfusion causes physiological and biochemical changes in the neuronal cells that will eventually lead to cell damage. Evidence indicates that exercise reduces the ischemia and reperfusion-induced brain damages in animal models of stroke. In the present study, the effect of exercise preconditioning on brain edema and neurological movement disorders following the cerebral ischemia and reperfusion in rats was investigated.
Twenty-one adult male wistar rats (weighing 260-300 g) were randomly divided into three groups: sham operated, exercise plus ischemia, and ischemia group (7 rats per group). The rats in exercise group were trained to run on a treadmill 5 days a week for 4 weeks. Transient focal cerebral ischemia and reperfusion were induced by middle cerebral artery occlusion (MCAO) for 60 minutes, followed by reperfusion for 23 hours. After 24 hours ischemia, movement disorders were tested by a special neurological examination. Also, cerebral edema was assessed by determining the brain water content.
The results showed that pre-ischemic exercise significantly reduced brain edema (P<0.05). In addition, exercise preconditioning decreased the neurological movement disorders caused by brain ischemia and reperfusion (P<0.05).
Preconditioning by exercise had neuroprotective effects against brain ischemia and reperfusion-induced edema and movement disorders. Thus, it could be considered as a useful strategy for prevention of ischemic injuries, especially in people at risk.
脑缺血再灌注会导致神经元细胞发生生理和生化变化，最终导致细胞损伤。有证据表明，运动可减轻中风动物模型中缺血再灌注引起的脑损伤。在本研究中，研究了运动预处理对大鼠脑缺血再灌注后脑水肿和神经运动障碍的影响。
将21只成年雄性Wistar大鼠（体重260 - 300克）随机分为三组：假手术组、运动加缺血组和缺血组（每组7只大鼠）。运动组的大鼠每周在跑步机上训练5天，持续4周。通过大脑中动脉闭塞（MCAO）60分钟诱导短暂性局灶性脑缺血再灌注，随后再灌注23小时。缺血24小时后，通过特殊的神经学检查测试运动障碍。此外，通过测定脑含水量评估脑水肿。
结果表明，缺血前运动可显著减轻脑水肿（P<0.05）。此外，运动预处理可减轻脑缺血再灌注引起的神经运动障碍（P<0.05）。
运动预处理对脑缺血再灌注引起的水肿和运动障碍具有神经保护作用。因此，它可被视为预防缺血性损伤的一种有用策略，尤其是对有风险的人群。
