用于生产[1-¹¹C]脂肪酸的计算机控制自动化合成系统。

Automated synthesis system with computer control for the production of [1-11C]fatty acids.

作者信息

Takahashi T, Ido T, Iwata R, Hatano K, Nakanishi H, Shinohara M, Iida S

机构信息

Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.

出版信息

Int J Rad Appl Instrum A. 1988;39(7):659-65. doi: 10.1016/0883-2889(88)90054-8.

DOI:10.1016/0883-2889(88)90054-8

PMID:2844700

Abstract

To accommodate the increasing need for [1-11C]fatty acids for use in routine medical studies and the large amounts of radioactivity required, a more advanced automated synthesis system for the preparation of [1-11C]fatty acids has been constructed. The synthesis of [1-11C]fatty acids has been completely automated using a new separation unit (isobaric Sepaltor) for the extraction procedure, which had caused some difficulties with automation. The yield of [1-11C]palmitic acid was 20-30 mCi, and that of 3-methyl [1-11C]heptadecanoic acid was 2-7 mCi. The time required for the synthesis was less than 30 min from the start of the 11CO2 trapping. This system has been used for more than 20 preparations of [1-11C]palmitic acid and more than 20 preparations of 3-methyl [1-11C]heptadecanoic acid.

摘要

为满足常规医学研究中对[1-¹¹C]脂肪酸日益增长的需求以及所需的大量放射性，已构建了一种更先进的用于制备[1-¹¹C]脂肪酸的自动化合成系统。使用一种新的分离单元（等压分离器）对提取过程进行了完全自动化处理，该提取过程在自动化方面曾存在一些困难。[1-¹¹C]棕榈酸的产量为20 - 30毫居里，3-甲基[1-¹¹C]十七烷酸的产量为2 - 7毫居里。从开始捕集¹¹CO₂起，合成所需时间不到30分钟。该系统已用于20多次[1-¹¹C]棕榈酸的制备以及20多次3-甲基[1-¹¹C]十七烷酸的制备。