通过自动连续流动过程制备¹¹C-碘甲烷和L-[S-甲基-¹¹C]蛋氨酸。

Preparation of 11C-methyl iodide and L-[S-methyl-11C]methionine by an automated continuous flow process.

作者信息

Davis J, Yano Y, Cahoon J, Budinger T F

出版信息

Int J Appl Radiat Isot. 1982 May;33(5):363-9. doi: 10.1016/0020-708x(82)90150-8.

Abstract

A continuous flow procedure has been developed for the synthesis of 11C-methyl iodide and L-[S-methyl-11C]methionine from 11CO2. The preparation can be completed in 20 min after the end of bombardment. This procedure results in the production of approximately 44 mCi 11C-methyl methionine with a specific activity of 3.3 Ci/mmol. Radiochemical purity is greater than 96%. The procedure has been automated so that the preparation can be carried out remotely, thus minimizing exposure of personnel to radiation.

摘要

已开发出一种连续流动程序，用于从(^{11}CO_2)合成(^{11}C -)甲基碘和(L - [S -)甲基(- ^{11}C])蛋氨酸。轰击结束后，该制备过程可在20分钟内完成。此程序可产生约44毫居里的(^{11}C -)甲基蛋氨酸，比活度为3.3居里/毫摩尔。放射化学纯度大于96%。该程序已实现自动化，因此制备过程可远程进行，从而将人员受辐射暴露降至最低。