Stegman James R, Margulies Barry J
Towson University Herpes Virus Lab, Towson University Department of Biology, Towson, MD, USA.
Towson University Molecular Biology, Biochemistry and Bioinformatics Training Program, Towson, MD, USA.
Virus Genes. 2017 Aug;53(4):516-521. doi: 10.1007/s11262-017-1462-y. Epub 2017 Apr 26.
The genome of human cytomegalovirus contains four genes that encode chemokine receptor homologs. Of these, the protein encoded by US27 is of particular interest today because it is currently one of the viral G-protein coupled receptors that remain classified as an orphan receptor. This review explains what is presently understood about this glycoprotein: its biochemistry, its location in infected cells, and its apparent function. While there are still many questions that remain about these topics and more, we also discuss the utility of the US27-encoded glycoprotein as a new target for antiviral intervention.
人类巨细胞病毒的基因组包含四个编码趋化因子受体同源物的基因。其中，由US27编码的蛋白质目前特别受关注，因为它是目前仍被归类为孤儿受体的病毒G蛋白偶联受体之一。这篇综述解释了目前对这种糖蛋白的了解：它的生物化学性质、在受感染细胞中的位置以及其明显的功能。虽然关于这些主题以及更多方面仍有许多问题，但我们也讨论了由US27编码的糖蛋白作为抗病毒干预新靶点的效用。
