Amsterdam Institute for Molecules Medicines and Systems, Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
Nat Rev Drug Discov. 2014 Feb;13(2):123-39. doi: 10.1038/nrd4189. Epub 2014 Jan 21.
Herpesviruses encode membrane-associated G protein-coupled receptors (GPCRs) in their viral genomes that are structurally similar to chemokine receptors. These GPCRs hijack GPCR-mediated cellular signalling networks of the host for survival, replication and pathogenesis. In particular the herpesvirus-encoded chemokine receptors ORF74, BILF1 and US28, which are present at inflammatory sites and tumour cells, provide important virus-specific targets for directed therapies. Given the high druggability of GPCRs in general, these viral GPCRs can be considered promising antiviral drug targets.
疱疹病毒在其病毒基因组中编码膜相关的 G 蛋白偶联受体（GPCR），这些 GPCR 在结构上与趋化因子受体相似。这些 GPCR 劫持宿主的 GPCR 介导的细胞信号网络来生存、复制和致病。特别是存在于炎症部位和肿瘤细胞中的疱疹病毒编码的趋化因子受体 ORF74、BILF1 和 US28，为靶向治疗提供了重要的病毒特异性靶点。鉴于 GPCR 通常具有较高的成药性，这些病毒 GPCR 可以被认为是有前途的抗病毒药物靶点。
