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Altered osmoregulation of ompF in integration host factor mutants of Escherichia coli.

作者信息

Tsui P, Helu V, Freundlich M

机构信息

Department of Biochemistry, State University of New York, Stony Brook 11794-5215.

出版信息

J Bacteriol. 1988 Oct;170(10):4950-3. doi: 10.1128/jb.170.10.4950-4953.1988.

DOI:10.1128/jb.170.10.4950-4953.1988
PMID:2844731
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC211544/
Abstract

Osmoregulation of the porin protein OmpF was strongly altered in integration host factor (IHF) mutants. These mutants produced approximately 15-fold more OmpF than did the parent strain when grown in media of intermediate osmolarity. At high osmolarity IHF mutants continued to produce considerable amounts of OmpF, although this protein was undetectable in the parent grown under these conditions. Experiments with an ompF-lacZ chromosomal fusion strain suggested that these changes in osmoregulation in large part involve alterations in transcriptional activity of the ompF promoter. These results add to the growing list of genes whose expression is modified in IHF mutants.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef0/211544/9b627ab0984d/jbacter00188-0533-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef0/211544/964dd77d33b8/jbacter00188-0532-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef0/211544/9b627ab0984d/jbacter00188-0533-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef0/211544/964dd77d33b8/jbacter00188-0532-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ef0/211544/9b627ab0984d/jbacter00188-0533-a.jpg

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Altered osmoregulation of ompF in integration host factor mutants of Escherichia coli.
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2
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本文引用的文献

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The ompB locus and the regulation of the major outer membrane porin proteins of Escherichia coli K12.大肠杆菌K12的ompB基因座与主要外膜孔蛋白的调控
J Mol Biol. 1981 Feb 15;146(1):23-43. doi: 10.1016/0022-2836(81)90364-8.
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Genetic analysis of the ompB locus in Escherichia coli K-12.大肠杆菌K-12中ompB基因座的遗传分析。
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SOS induction and autoregulation of the himA gene for site-specific recombination in Escherichia coli.大肠杆菌中用于位点特异性重组的himA基因的SOS诱导及自动调节。
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Alterations of the outer membrane composition in Escherichia coli lacking the histone-like protein HU.缺乏类组蛋白HU的大肠杆菌外膜成分的改变
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A distant upstream site involved in the negative regulation of the Escherichia coli ompF gene.一个参与大肠杆菌ompF基因负调控的远上游位点。
J Bacteriol. 1994 Mar;176(5):1309-15. doi: 10.1128/jb.176.5.1309-1315.1994.
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Modulation of flagellar expression in Escherichia coli by acetyl phosphate and the osmoregulator OmpR.乙酰磷酸和渗透压调节因子OmpR对大肠杆菌鞭毛表达的调控
J Bacteriol. 1995 Aug;177(16):4696-702. doi: 10.1128/jb.177.16.4696-4702.1995.
8
Phosphorylation-dependent conformational changes in OmpR, an osmoregulatory DNA-binding protein of Escherichia coli.磷酸化依赖性构象变化在大肠杆菌的渗透压调节性DNA结合蛋白OmpR中发生。
Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8866-70. doi: 10.1073/pnas.92.19.8866.
9
Searching for and predicting the activity of sites for DNA binding proteins: compilation and analysis of the binding sites for Escherichia coli integration host factor (IHF).寻找和预测DNA结合蛋白的结合位点活性：大肠杆菌整合宿主因子（IHF）结合位点的汇编与分析
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10
Integration host factor is a negative effector of in vivo and in vitro expression of ompC in Escherichia coli.整合宿主因子是大肠杆菌中ompC基因在体内和体外表达的负调控因子。
J Bacteriol. 1990 Sep;172(9):5293-8. doi: 10.1128/jb.172.9.5293-5298.1990.
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6754-8. doi: 10.1073/pnas.78.11.6754.
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Mutation causing reverse osmoregulation of synthesis of OmpF, a major outer membrane protein of Escherichia coli.导致大肠杆菌主要外膜蛋白OmpF合成发生反向渗透调节的突变。
J Bacteriol. 1984 Aug;159(2):688-92. doi: 10.1128/jb.159.2.688-692.1984.
5
Reduced expression of the isoleucine and valine enzymes in integration host factor mutants of Escherichia coli.大肠杆菌整合宿主因子突变体中异亮氨酸和缬氨酸酶的表达降低。
J Mol Biol. 1984 Feb 5;172(4):573-9. doi: 10.1016/s0022-2836(84)80024-8.
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Regulation of outer membrane porin protein synthesis in Escherichia coli K-12: ompF regulates the expression of ompC.大肠杆菌K-12中外膜孔蛋白合成的调控：ompF调控ompC的表达。
J Bacteriol. 1983 May;154(2):669-75. doi: 10.1128/jb.154.2.669-675.1983.
7
Primary structure of the ompF gene that codes for a major outer membrane protein of Escherichia coli K-12.编码大肠杆菌K-12主要外膜蛋白的ompF基因的一级结构。
Nucleic Acids Res. 1982 Nov 11;10(21):6957-68. doi: 10.1093/nar/10.21.6957.
8
Osmoregulation of gene expression. I. DNA sequence of the ompR gene of the ompB operon of Escherichia coli and characterization of its gene product.基因表达的渗透调节。I. 大肠杆菌ompB操纵子ompR基因的DNA序列及其基因产物的特性
J Biol Chem. 1982 Nov 25;257(22):13685-91.
9
Purification and properties of the Escherichia coli protein factor required for lambda integrative recombination.λ整合重组所需的大肠杆菌蛋白质因子的纯化及特性
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10
Synergistic effect of himA and gyrB mutations: evidence that him functions control expression of ilv and xyl genes.himA和gyrB突变的协同效应：him功能控制ilv和xyl基因表达的证据。
J Bacteriol. 1984 Feb;157(2):484-9. doi: 10.1128/jb.157.2.484-489.1984.