食管鳞状细胞癌患者血清血管内皮生长因子受体-3水平
Serum vascular endothelial growth factor receptor-3 levels in patients with esophageal squamous cell cancer.
作者信息
Su Mer Aziz, Demir Ali, Kemik Ahu Sarbay, Yavuz Alpaslan, Suvak Burak, Du Lger Ahmet Cumhur, Purisa Sevim, Kemik Ozgur
出版信息
Ann Ital Chir. 2017;88:20-25.
AIM
Esophageal cancer is one of the most aggressive tumors of the gastrointestinal tract. In this study, we quantified the serum vascular endothelial growth factor-3 (VEGFR-3) expression in patients with esophageal squamous cell carcinoma (ESCC) to evaluate the role of VEGFR-3 in ESCC.
MATERIALS AND METHODS
Ninety five patients with ESCC were studied. Pre-therapy and preoperative samples were stored and ELISA was used to designate the concentrations of VEGFR-3.
RESULTS
The serum values of VEGFR-3 were significantly higher in patients with ESCC than in healthy donors (p<0.0001).
CONCLUSIONS
The results imply a very good sensitivity of VEGFR-3 in ESCC. VEGFR-3 may be a good diagnostic biomarker for ESCC.
KEY WORDS
Biomarker, ESCC, VEGFR-3.
目的
食管癌是胃肠道中侵袭性最强的肿瘤之一。在本研究中，我们对食管鳞状细胞癌（ESCC）患者血清血管内皮生长因子-3（VEGFR-3）的表达进行定量，以评估VEGFR-3在ESCC中的作用。
材料与方法
研究了95例ESCC患者。保存治疗前和术前样本，采用酶联免疫吸附测定法（ELISA）测定VEGFR-3的浓度。
结果
ESCC患者的血清VEGFR-3值显著高于健康供体（p<0.0001）。
结论
结果表明VEGFR-3在ESCC中具有很高的敏感性。VEGFR-3可能是ESCC的一种良好诊断生物标志物。
关键词
生物标志物；ESCC；VEGFR-3
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