Taimour Soumia, Zarrouk Moncef, Holst Jan, Melander Olle, Engström Gunar, Smith J Gustav, Gottsäter Anders
1 Department of Vascular Diseases, Lund University, Malmö, Sweden.
2 Clinical Research Unit, Department of Internal Medicine, Lund University, Malmö, Sweden.
Vasa. 2017 Jul;46(4):291-295. doi: 10.1024/0301-1526/a000632. Epub 2017 Apr 27.
Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.
To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men) aged 47-49 in a prospective population-based cohort study, and related to aortic diameter at US examination of the aorta after 14-19 years of follow-up.
Biomarker levels at baseline did not correlate with aortic diameter after 14-19 years of follow up (CRP [r = 0.153], PNT [r = 0.070], CPT [r = -.156], Lp-PLA2 [r = .024], Cyst C [r = -.015], MR-proANP [r = 0.014], MR-proADM [r = -.117]). Adjusting for age and smoking at baseline in a linear regression model did not reveal any significant correlations.
Tested biomarker levels at age 47-49 were not associated with aortic diameter at ultrasound examination after 14-19 years of follow-up. If there are relationships between these biomarkers and aortic dilatation, they are not relevant until closer to AAA diagnosis.
反映多种病理生理途径的生物标志物可能在腹主动脉瘤（主动脉直径≥30mm，AAA）的发病机制中起重要作用，在接受腹主动脉瘤超声（US）筛查的65岁男性中，许多生物标志物水平升高且与主动脉直径相关。
为了评估长期随访后生物标志物与主动脉扩张之间的潜在关系，在一项基于人群的前瞻性队列研究中，对117名年龄在47 - 49岁的受试者（114名[97%]男性）测量了C反应蛋白（CRP）、前神经降压素（PNT）、 copeptin（CPT）、脂蛋白相关磷脂酶2（Lp - PLA2）、胱抑素C（Cyst C）、中段心房利钠肽前体（MR - proANP）和中段肾上腺髓质素前体（MR - proADM）的水平，并将其与随访14 - 19年后主动脉超声检查时的主动脉直径相关联。
随访14 - 19年后，基线时的生物标志物水平与主动脉直径无相关性（CRP[r = 0.153]，PNT[r = 0.070]，CPT[r = - 0.156]，Lp - PLA2[r = 0.024]，Cyst C[r = - 0.015]，MR - proANP[r = 0.014]，MR - proADM[r = - 0.117]）。在直线回归模型中对基线时的年龄和吸烟情况进行校正后，未发现任何显著相关性。
47 - 49岁时检测的生物标志物水平与随访14 - 19年后超声检查时的主动脉直径无关。如果这些生物标志物与主动脉扩张之间存在关系，则在更接近腹主动脉瘤诊断之前并不相关。
