Ku Çu K Adem, Topaloglu Naci, Yildirim Sule, Tekin Mustafa, Erbas Mesut, Kiraz Hasan Ali, Erdem Havva, Özkan Aybars
Ann Ital Chir. 2017;88:82-86.
Accidental caustic ingestions are serious medical problems especially in childhood. Various treatment modalities are being used for the complications of caustic injuries such as stricture formation. The aim of this study is to establish whether ursodeoxycholic acid (UDCA) has protective effects on experimental corrosive esophagitis in rats. Twenty four Wistar-albino rats, weighing 220-240 g, were used in the study. Experimental animals were divided in three groups randomly: UDCA treatment group (Group T, n:8), control group (Group K, n: 8) and sham group (Group S, n: 8). In group T and S corrosive esophagitis was induced. UDCA (5 mg/kg) was performed to the group T for 10 days orally. All animals were sacrificed at the end of procedures and histopathological changes in esophageal tissue were scored by a single investigator who was blind to the groups. In group T inflammation was present in two rats, muscularis mucosa injury in two rats, grade 1 collagen deposition in six rats and grade 2 in two rats. In comparison with group S these were statistically significant (p value was 0.003, 0.003 and 0.015, respectively). UDCA has protective effect in experimental corrosive esophagitis.
Corrosive esophagitis, Rat, Stricture, Ursodeoxycholic acid.
意外摄入苛性剂是严重的医学问题，尤其是在儿童时期。各种治疗方式被用于治疗诸如狭窄形成等苛性损伤的并发症。本研究的目的是确定熊去氧胆酸（UDCA）对大鼠实验性腐蚀性食管炎是否具有保护作用。本研究使用了24只体重220 - 240克的Wistar白化大鼠。实验动物被随机分为三组：UDCA治疗组（T组，n = 8）、对照组（K组，n = 8）和假手术组（S组，n = 8）。在T组和S组诱导产生腐蚀性食管炎。对T组大鼠口服UDCA（5毫克/千克），持续10天。所有动物在实验结束时被处死，由一位对分组情况不知情的研究者对食管组织的组织病理学变化进行评分。在T组中，两只大鼠出现炎症，两只大鼠出现黏膜肌层损伤，六只大鼠出现1级胶原沉积，两只大鼠出现2级胶原沉积。与S组相比，这些差异具有统计学意义（p值分别为0.003、0.003和0.015）。UDCA对实验性腐蚀性食管炎具有保护作用。
腐蚀性食管炎；大鼠；狭窄；熊去氧胆酸
