Henchoz Y, Büla C, Guessous I, Santos-Eggimann B
Yves Henchoz; Institute of Social and Preventive Medicine (IUMSP), University of Lausanne Hospital Centre, Route de la Corniche 10, CH-1010 Lausanne, Switzerland;
J Nutr Health Aging. 2017;21(5):585-592. doi: 10.1007/s12603-016-0772-4.
Though the association between physical frailty and health is well established, little is known about its association with other domains of quality of life (QoL). This study investigated the association between physical frailty and multiple domains of QoL in community-dwelling older people.
Cross-sectional study.
Data of the 2011 annual assessment of 927 older people (age 73-77 years) from the Lc65+ cohort study were used.
Physical frailty was assessed by Fried's five criteria: 'shrinking'; 'weakness'; 'poor endurance, exhaustion'; 'slowness'; and 'low activity'. QoL was assessed using 28 items yielding a QoL score and seven domain-specific QoL subscores (Feeling of safety; Health and mobility; Autonomy; Close entourage; Material resources; Esteem and recognition; and Social and cultural life). Low QoL (QoL score or QoL subscores in the lowest quintile) was used as dependent variable in logistic regression analyses adjusted for age and sex (model 1), and additionally for socioeconomic (model 2) and health (model 3) covariates.
Physical frailty was associated with a low QoL score, as well as decreased QoL subscores in all seven specific domains, even after adjusting for socio-economic covariates. However, when performing additional adjustment for health covariates, only the domain Health and mobility remained significantly associated with physical frailty. Among each specific Fried's criteria, 'slowness' had the strongest association with a low QoL score.
Physical frailty is associated with all QoL domains, but these associations are largely explained by poor health characteristics. Longitudinal studies are needed to better understand temporal relationships between physical frailty, health and QoL.
尽管身体虚弱与健康之间的关联已得到充分证实，但对于其与生活质量（QoL）其他领域的关联却知之甚少。本研究调查了社区居住的老年人身体虚弱与多个生活质量领域之间的关联。
横断面研究。
使用了来自Lc65 +队列研究的927名老年人（年龄73 - 77岁）2011年度评估的数据。
身体虚弱通过弗里德的五项标准进行评估：“体型缩小”；“虚弱”；“耐力差、易疲惫”；“行动迟缓”；以及“活动量低”。生活质量使用28个项目进行评估，得出生活质量得分以及七个特定领域的生活质量子得分（安全感；健康与 mobility；自主性；亲密陪伴；物质资源；自尊与认可；以及社会与文化生活）。低生活质量（生活质量得分或生活质量子得分处于最低五分位数）在针对年龄和性别进行调整的逻辑回归分析中用作因变量（模型1），并额外针对社会经济因素（模型2）和健康因素（模型3）协变量进行调整。
即使在对社会经济协变量进行调整之后，身体虚弱仍与低生活质量得分以及所有七个特定领域的生活质量子得分降低相关。然而，在对健康协变量进行额外调整后，只有“健康与 mobility”领域仍与身体虚弱显著相关。在弗里德的各项特定标准中，“行动迟缓”与低生活质量得分的关联最为强烈。
身体虚弱与所有生活质量领域相关，但这些关联在很大程度上可由不良健康特征来解释。需要进行纵向研究以更好地理解身体虚弱、健康与生活质量之间的时间关系。
